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TranscriptomicsHemangioblast skewing from embryonic stem(ES) cells by defined factors
Successful derivation of a specific cell lineage from pluripotent stem cells will tremendously facilitate the clinical usage of pluripotent stem derived somatic cells. Herein, we demonstrate that ER71/Etv2, GATA2 and Scl form a core network in hemangioblast development and that transient co-expressi...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-45147 | biostudies-arrayexpress
TranscriptomicsExpression data from day 3 Flk-1 mesoderm between ER71 overexpressed and ER71 knockout mouse embryonic stem cell
Ets transcription factor ER71 is critical for Flk-1 mesoderm specification to different cell lineages. In this dataset, we determine to investigate the mechanisms by which ER71 regulates hematopoietic and endothelial cell versus cardiac cell lineage development. Expression of all four Flk-1+ mesoder...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35793 | biostudies-arrayexpress
TranscriptomicsFactors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast
Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found at all centromeres. However, the mechanisms that specify the locations at which CENP-A chromatin is assembled remain elusive in organisms with regional, epigenetically regulated centromeres. It is known that norma...
ORGANISM(S): Schizosaccharomyces pombe 
2015-02-19 | E-GEOD-66106 | biostudies-arrayexpress
GenomicsWhole-genome landscape of histone H2AX and M-NM-3-H2AX
Phosphorylation of the histone variant H2AX forms M-NM-3-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and M-NM-3-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endoge...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
UnknownOptimization of crystal packing in semiconducting spin-crossover materials with fractionally charged TCNQ δ- anions (0 < δ < 1).
Not available
S-EPMC8372557 | biostudies-literature
UnknownEngraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes.
Not available
S-EPMC4142041 | biostudies-literature
GenomicsGenome-wide analysis of ETS factor ER71/ETV2 chromatin occupancy
We discover that ER71/ETV2 initiates hemangiogenic program by activating blood and endothelial cell lineage specifying genes while enhancing FLK1 expression and expanding hemangioblast population. Furthermore, ER71/ETV2 establishes an ETS hierarchy by directly activating Ets genes in hematopoietic a...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-59402 | biostudies-arrayexpress
UnknownIn vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Not available
S-EPMC3585072 | biostudies-literature
UnknownBooster vaccination with Ad26.COV2.S or an Omicron-adapted vaccine in pre-immune hamsters protects against Omicron BA.2.
Not available
S-EPMC10018069 | biostudies-literature
TranscriptomicsDifferentiation stage-specific donor memory in induced pluripotent stem cells (iPSC) generated from hepatic lineage cells
Recent studies suggested that embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) may represent different pluripotent states as defined by gene expression profiles and differentiation potential. Here we addressed a contribution of a lineage stage-specific donor cell memory in mod...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-33110 | biostudies-arrayexpress
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