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UnknownThe Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement.

Background and purpose

Rapid population aging and an increase in the demented elderly became major social concerns in South Korea. Environmental design is increasingly recognized as an important aid for long-term care of patients with dementia as well as pharmacotherapy. We did a pilot study...
S-EPMC7781737 | biostudies-literature
UnknownIdentification of suitable reference genes for the relative quantification of microRNAs in pleural effusion.
Circulating cell-free microRNAs (miRNAs) are potential biomarkers of cancer. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is widely used in miRNA expression studies. The aim of this study was to identify suitable reference genes for RT-qPCR analyses of miRNA expression leve...
S-EPMC4156210 | biostudies-literature
UnknownDistinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.
T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell aplasia (PRCA). A high depth of next generation sequencing (NGS) was used for detection of the mutational profiles in T-LGL alone (n = 25) and T-LGL combined with PRCA (n = 16). Beside STAT3 mutation (41.5%), the...
S-EPMC10160083 | biostudies-literature
UnknownReliability of brain volume measures of accelerated 3D T1-weighted images with deep learning-based reconstruction.

Purpose

The time-intensive nature of acquiring 3D T1-weighted MRI and analyzing brain volumetry limits quantitative evaluation of brain atrophy. We explore the feasibility and reliability of deep learning-based accelerated MRI scans for brain volumetry.

Methods

This retrospective stud...
S-EPMC11802604 | biostudies-literature
UnknownExploratory evidence of mitigated immune imprinting following concomitant COVID-19 and influenza vaccination.
Concomitant administration of coronavirus disease (COVID-19) and influenza vaccination schedules has been widely adopted. However, long-term data on the immunological impact, particularly on variant-specific responses, remain limited. In this 10-month prospective study, 80 participants (40 per group...
S-EPMC12749089 | biostudies-literature
UnknownStretchable PPG sensor with light polarization for physical activity-permissible monitoring.
Skin-attachable sensors, which represent the ultimate form of wearable electronic devices that ensure conformal contact with skin, suffer from motion artifact limitations owing to relative changes in position between the sensor and skin during physical activities. In this study, a polarization-selec...
S-EPMC9007514 | biostudies-literature
UnknownDeep learning-based quantification of T2-FLAIR mismatch sign: extending IDH mutation prediction in adult-type diffuse lower-grade glioma.

Objectives

To investigate the predictive value of the quantitative T2-FLAIR mismatch ratio (qT2FM) with fully automated tumor segmentation in adult-type diffuse lower-grade gliomas (LGGs).

Materials and methods

This retrospective study included 218 consecutive patients (mean age, 47 y...
S-EPMC12350433 | biostudies-literature
UnknownClopidogrel monotherapy in patients with and without on-treatment high platelet reactivity: a SMART-CHOICE substudy.

Background

Although P2Y12 inhibitor monotherapy has emerged as a promising alternative for dual antiplatelet therapy (DAPT), there remains concern regarding the safety of clopidogrel monotherapy.

Aims

We sought to investigate clinical outcomes of clopidogrel monotherapy in patients wi...
S-EPMC9724997 | biostudies-literature
UnknownCombination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice.
As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of variants of concern, there is an immediate need to implement the most effective antiviral treatment strategies, especially for risk groups. Here, we evaluated the therapeutic potency of nirmatrelvir, remdesivir and ...
S-EPMC9535923 | biostudies-literature
UnknownUnsustainable and overworked: unpacking the challenges faced by pediatric cardiologists and cardiac surgeons in Korea.

Background

Pediatric cardiologists (PCs) and pediatric cardiac surgeons (PedCSs) in Korea face growing workforce shortages due to declining birth rates, decreasing interest among trainees, and increasing burnout.

Purpose

This study investigated the working conditions, job satisfaction...
S-EPMC12409189 | biostudies-literature
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