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TranscriptomicsA novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix
The increased M-NM-1-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-cultu...
ORGANISM(S): Rattus norvegicus 
2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress
MetabolomicsComprehensive analysis of transcriptome and metabolome in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma
Not available
ORGANISM(S): Homo sapiens 
ST000230 | MetabolomicsWorkbench
GenomicsMassive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). Methods: mRNA and...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63420 | biostudies-arrayexpress
TranscriptomicsLow-power photodynamic therapy induces survival signaling in cultured hilar cholangiocarcinoma cells
Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizerreplete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature and inducti...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-68292 | biostudies-arrayexpress
MetabolomicsComprehensive analysis of transcriptome and metabolome in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000231 | MetabolomicsWorkbench
TranscriptomicsWTAP-induced change in gene expresssion in cholangiocarcinoma cells
Knock-down or overexpression of WTAP regulated migration and invasion of cholangiocarcinoma cells in vivo and vitro studies. To investigate the underlying mechanism for WTAP-regulated migration and invasion, the gene expression between the mock cells and the stable cells was compared Total RNA was p...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-GEOD-32134 | biostudies-arrayexpress
ProteomicsTWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression
Cholangiocarcinoma is a cancer of the hepatic bile ducts that is typically detected at a stage too advanced for resection. Additionally, chemotherapy is of limited efficacy, hence, novel therapeutic approaches are urgently required, including targeting of the cancer stroma. A macrophage-derived sign...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084273 | MassIVE
TranscriptomicsMolecular classification of human cholangiocarcinoma
Transcriptomic profiling Background Cholangiocarcinoma accounts for 5-10% of primary hepatic cancers. The etiology is unclear and patients are often diagnosed without risk factors. Resection is the only curative treatment although patients frequently remain undiagnosed until advanced stage of disea...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-26566 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6
The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by a...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11883 | biostudies-arrayexpress
ProteomicsCharacterization of the cholangiocarcinoma stem cells by proteomics
Comparison of global proteome between stem cells, differentiating stem cells, and parental cells of cholangiocarcinoma.
ORGANISM(S): Homo Sapiens (human) 
2024-02-08 | PXD039953 | JPOST Repository
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