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ProteomicsIdentification of novel biomarker candidates for the immunohistochemical diagnosis of cholangiocellular carcinoma - LC-MS Part
The aim of this study was the identification of biomarkers for the immunohistochemical diagnosis of cholangiocellular carcinoma (CCC). CCC is a primary cancer which arises from the epithelial cells of the bile ducts and is characterised by high mortality rates due to its late clinical presentation a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082885 | MassIVE
ProteomicsImmunohistochemical markers distinguishing cholangiocellular carcinoma from pancreatic ductal adenocarcinoma discovered by proteomic analysis of microdissected cells
Cholangiocellular carcinoma (CCC) and pancreatic ductal adenocarcinoma (PDAC) are two highly aggressive cancer types which arise from epithelial cells of the pancreatobiliary system. Due to their histologic and morphologic similarity, differential diagnosis between CCC and metastasis of PDAC located...
ORGANISM(S): Homo sapiens (Human) 
2015-12-10 | PXD001833 | Pride
Cholangiocellular carcinoma Pancreatic ductal adenocarcinoma Laser capture microdissection Biomarker Lc-ms/ms 
ProteomicsIdentification of novel biomarker candidates for the immunohistochemical diagnosis of cholangiocellular carcinoma - LC-MS Part
The aim of this study was the identification of biomarkers for the immunohistochemical diagnosis of cholangiocellular carcinoma (CCC). CCC is a primary cancer which arises from the epithelial cells of the bile ducts and is characterised by high mortality rates due to its late clinical presentation a...
ORGANISM(S): Homo sapiens (Human) 
2014-07-21 | PXD000534 | Pride
Human Lc-ms Maldi Liver Cholangiocellular carcinoma 
TranscriptomicsIntegrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma [miRNA]
We compared transcriptomic profiles of ICC tumor specimens to hepatocellular carcinoma (HCC) specimens using Affymetrix mRNA array and the miRNA array platforms to search for unique gene signatures linked to patient prognosis. ICC and HCC share common stem-like molecular characteristics and stem-lik...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-32957 | biostudies-arrayexpress
ProteomicsHuman Bile LC-MS/MS
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082926 | MassIVE
TranscriptomicsIdentification of cholangiocarcinoma-like gene expression traits in hepatocellular carcinoma
We performed gene expression profiling of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and mixed type of combined HCC and CC (CHC). In comparison of the profiles, a novel class of HCC expressing CC-like traits was identified. Gene expression profiling of 70 hepatocellular carcinoma (HCC)...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-15765 | biostudies-arrayexpress
UnknownSelective internal radiotherapy (SIRT) versus transarterial chemoembolization (TACE) for the treatment of intrahepatic cholangiocellular carcinoma (CCC): study protocol for a randomized controlled trial.
Not available
S-EPMC4132905 | biostudies-literature
TranscriptomicsTranscription profiling by array of human Intrahepatic Cholangiocarcinoma (ICC) and Combined Hepatocellular Cholangiocarcinoma (CHC) tumors
We compared transcriptomic profiles of 23 ICC tumor specimens to hepatocellular carcinoma (HCC) specimens using Affymetrix mRNA array and the miRNA array platforms to search for unique gene signatures linked to patient prognosis. ICC and HCC share common stem-like molecular characteristics and stem-...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-32879 | biostudies-arrayexpress
GenomicsMassive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). Methods: mRNA and...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63420 | biostudies-arrayexpress
TranscriptomicsIntegrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma
This SuperSeries is composed of the following subset Series: GSE32879: Integrative Transcriptomic Profiling reveals Hepatic Stem-like Phenotype and Interplay of EMT and miR-200c in Intrahepatic Cholangiocarcinoma [mRNA] GSE32957: Integrative Transcriptomic Profiling reveals Hepatic Stem-like Phenoty...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-32958 | biostudies-arrayexpress
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