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TranscriptomicsIdentification of Novel Cholesteatoma-related Gene Expression Signatures Using Full-genome Microarrays
In this study, we investigated differentially expressed genes in human cholesteatomas in comparison to regular auditory canal skin using Whole Human Genome Microarrays that contain 19,596 human genes. In addition to already described up-regulated mRNAs in cholesteatoma, such as MMP9, DEFB2 and KRT1...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-42256 | biostudies-arrayexpress
ProteomicsLarge scale proteomics of cholesteatoma
The study describes comprehensive proteomics data of the cholesteatoma disease. Cholesteatoma is a serious and destructive growth of keratinizing squamous epithelium in the middle ear, with a poorly understood etiopathogenesis. The large scale proteomics approach used in this study highly expands ou...
ORGANISM(S): Homo sapiens (Human) 
2014-06-04 | PXD000457 | Pride
Biopsy Tympanic membrane Mucosa Middle ear Patient Cholesteatoma Epithel 
GenomicsFibroblasts in cholesteatoma activate osteoclasts.
Fibroblasts in cholesteatoma activate osteoclasts.
PRJNA477370 | ENA
GenomicsWhole exome sequencing study of cholesteatoma patients from affected families
This study used whole exome sequencing on 21 patients with cholesteatoma from 10 families in order to identify variants that may attribute to cholesteatoma aetiology.
EGAS00001006147 | EGA
ProteomicsTMT-based LC-MS/MS proteomics of cholesteatoma
Eight cases of middle ear cholesteatoma specimens and matched ear canal skin specimens
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD036926 |
TranscriptomicsFibroblasts in cholesteatoma activate osteoclasts.
Cholesteatoma arises from a tympanic membrane and expands in the middle ear. It erodes the surrounding bone and leads to hearing loss or brain abscess which is lethal complication. Currently, the only effective treatment is the complete surgical removal of cholesteatoma. However, possibility of recu...
ORGANISM(S): Homo sapiens 
2019-06-30 | GSE116142 | GEO
GenomicsN6-methyladenosine methylation landscape of human normal skin and middle ear cholesteatoma
N6-methyladenosine methylation landscape of human normal skin and middle ear cholesteatoma
PRJNA998414 | ENA
GenomicsMicroarray analysis and functional prediction of differentially-expressed circular RNAs in acquired middle ear cholesteatoma
Microarray analysis and functional prediction of differentially-expressed circular RNAs in acquired middle ear cholesteatoma
PRJNA718088 | ENA
OtherN6-methyladenosine methylation landscape of human normal skin and middle ear cholesteatoma
To determine the lncRNA and mRNA m6A quantity and expression profile in middle ear cholesteatoma and normal skin tissues, we used lncRNA and mRNA epitranscriptome microArray analysis from Arraystar to examine the RNA m6A and expression levels in middle ear cholesteatoma and normal skin tissues.
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE238238 | GEO
TranscriptomicsSingle-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction
To elucidate the mechanism underlying bone erosion in cholesteatoma, we performed scRNA-seq using human cholesteatoma tissues surgically resected from patients. We focused on pathogenic fibroblasts or keratinocytes, and therefore CD45-negative cells were collected for scRNA-seq analysis to exclude h...
ORGANISM(S): Homo sapiens 
2023-05-29 | GSE210261 | GEO
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