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MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
TranscriptomicsDiet and phenobarbital affect cholesterol homeostasis and drug metabolism
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were analyzed using Sterolgene v0 cDNA microarrays. Sterolgene microarray is a tool designe...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-6447 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Experiment Overall Design: One group of mic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ApoE3Leiden mice exposed to varying doses of cholesterol to examine the effects of dietary cholesterol on liver homeostasis in the context of early atherosclerotic lesion development
A dose-response study of the effects of dietary cholesterol on liver homeostasis in the context of early atherosclerotic lesion development using ApoE3Leiden mice
ORGANISM(S): Mus musculus 
2007-10-13 | E-TABM-253 | biostudies-arrayexpress
TranscriptomicsPeturbation of PICALM Levels Alters Cellular Cholesterol Metabolism
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PI...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-64855 | biostudies-arrayexpress
TranscriptomicsEffect of TCPOBOP, PCN, rosuvastatin, and atorvastatinin on cholesterol homeostasis
This SuperSeries is composed of the following subset Series: GSE13688: Effect of TCPOBOP and PCN in combination with high-cholesterol diet on genes involved in cholesterol homeostasis GSE13689: Effect of rosuvastatin and atorvastatin in combination with high-cholesterol diet on cholesterol homeostas...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-13721 | biostudies-arrayexpress
TranscriptomicsTNFalpha interferes with adaptation to starvation and activates pro-atherogenic processes
Pathenogenesis of atherosclerosis results from the interactions between disrupted lipid homeostasis and immune response, but the molecular bridges between the major players are still a matter of controversy. We performed a systemic study of the imflammatory cytokine tumor necrosis factor alpha (TNF ...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-6423 | biostudies-arrayexpress
MetabolomicsNatural photosynthetic system for restoring homeostasis of animal organelle interaction network

Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Current treatments usually focus on individual organelles while ignoring the role of organelle interactions in cell damage caused by cascade reactions. The...

2026-01-20 | MTBLS13730 | MetaboLights
MetabolomicsOxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Not available
ORGANISM(S): Mus musculus 
ST002280 | MetabolomicsWorkbench
TranscriptomicsWnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high content genome-wide RNAi screens that monitored lipid distribution and amounts, we find...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-MTAB-2872 | biostudies-arrayexpress
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