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MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsUntargeted metabolomics sheds light on the secondary metabolism of fungi triggered by choline-based ionic liquids
Fungal secondary metabolites constitute a rich source of yet undiscovered bioactive compounds. Their production is often silent under standard laboratory conditions, but the production of some compounds can be triggered simply by altering the cultivation conditions. The usage of an organic salt - io...
2022-07-15 | MTBLS5072 | MetaboLights
TranscriptomicsIntegrated analysis of the transcriptome-lipidome reveals the interactions of inositol-choline and SNF1 in controlling lipid biosynthesis
Characterize the transcriptional response to inositol-choline and snf1 We used microarrays to capture the global responses of inositol-choline concentration and snf deletion in Carbon and Nitrogen limited growth
ORGANISM(S): Saccharomyces cerevisiae 
2012-08-29 | E-GEOD-32418 | biostudies-arrayexpress
TranscriptomicsInterstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of inte...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62362 | biostudies-arrayexpress
TranscriptomicsAberrant choline metabolism in epithelial ovarian cancer: relevance of choline kinase activity and expression
Detection of the abnormal phosphatidylcholine (PtdCho) metabolism in EOC by analysis of magnetic resonance profile (MRS), showed a significant increase of PCho content in EOC cells as compared with non tumoral counterparts associated with activation of choline kinase (ChoK), the enzyme responsible f...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-39943 | biostudies-arrayexpress
MetabolomicsLipidomics of brown adipocytes treated with d9-choline
Not available
ORGANISM(S): Mus musculus 
ST001960 | MetabolomicsWorkbench
MetabolomicsKidney choline acetyltransferase (ChAT)-3
Not available
ORGANISM(S): Mus musculus 
ST000376 | MetabolomicsWorkbench
MetabolomicsKidney choline acetyltransferase (ChAT)-(part II)
Not available
ORGANISM(S): Rattus norvegicus 
ST000377 | MetabolomicsWorkbench
TranscriptomicsGene expression data for two xenograft models representing luminal-like and basal-like breast cancer
Choline (reference 1) and glucose (reference 2) was studied using HR MAS MR spectroscopy data and 105 and 38 gene transcripts were selected respectively from the microarray data to study differences between two xenograft models. Reference 1: Moestue SA et al, Distinct choline metabolic profiles are ...
ORGANISM(S): Homo sapiens 
2010-12-08 | E-GEOD-25915 | biostudies-arrayexpress
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