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ProteomicsSemi-automated Glycoproteomic Data Analysis of LC-MS data using GlycopeptideGraphMS in Lead and Process Development of Biologics
The glycosylation of antibody-based proteins is vital in conferring the right therapeutic outcomes of the patient. Despite this, significant infrastructure is required to analyse biologic glycosylation in various unit operations from biologic development, process development to QA/QC in bio-manufact...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025299 | Pride
Glycoproteomic Biologics Trastuzumab Bioaccord Igg Adalimumab Graphms Process development 
ProteomicsModelling ferroptosis in a human microglial line by sequential exposure to iron and GPX4 inhibition
Excessive iron accumulation is a pathological feature of several neurodegenerative diseases (NDDs) and a growing body of evidence suggests that ferroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, is implicated in their pathogenesis. Microglia, the brain's ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD079947 | Pride
Ferroptosis Lipid metabolism Oxidative stress Microglia Neurodegeneration 
MetabolomicsDivergent relationships between faecal microbiota and metabolome following distinct antibiotic-induced disruptions
The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic relationships that exist between members of the intestinal m...
2017-03-03 | MTBLS422 | MetaboLights
UnknownSynergistic Effects of N-Acetylcysteine and Mesenchymal Stem Cell in a Lipopolysaccharide-Induced Interstitial Cystitis Rat Model.
Not available
S-EPMC7017055 | biostudies-literature
ProteomicsComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GB...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-13 | PXD012487 | Pride
Gabab receptors Cellular neuroscience Lc-ms/ms 
UnknownTherapeutic Efficacy of Human Embryonic Stem Cell-Derived Multipotent Stem/Stromal Cells in Diabetic Detrusor Underactivity: A Preclinical Study.
Not available
S-EPMC7563486 | biostudies-literature
UnknownA Preclinical Study of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells for Treating Detrusor Underactivity by Chronic Bladder Ischemia.
Not available
S-EPMC8599399 | biostudies-literature
UnknownLongitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitial cystitis/bladder pain syndrome.
Not available
S-EPMC6276303 | biostudies-literature
TranscriptomicsDynamic developmental signaling logic underlying lineage bifurcations during human endoderm induction and patterning from pluripotent stem cells [Endoderm RNA-seq and ChIP-seq data sets]
Unraveling complex signaling programs animating developmental lineage-decisions is pivotal to differentiate human pluripotent stem cells (hPSC) into pure populations of desired lineages for regenerative medicine. Developmental signals are strikingly temporally dynamic: BMP and Wnt initially specify ...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-52657 | biostudies-arrayexpress
TranscriptomicsSystems Toxicology Identifies Mechanistic Impacts of 2-amino-4,6-dinitrotoluene (2-ADNT) Exposure in Northern Bobwhite
A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to pursue a holistic understanding of the effects of the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT) dosing on the health of the wildlife bird model, Northern bobwhi...
ORGANISM(S): Colinus virginianus 
2015-07-01 | E-GEOD-59910 | biostudies-arrayexpress
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