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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
TranscriptomicsTranscription profiling by array of human chorionic villus samples from preeclampsia patients
4 chorionic villus sampling specimens in pregnancies destined for preeclampsia and 8 matched controls were analyzed; 36 genes were differentially expressed using J5 score and prediction modeling in caGEDA computer program Experiment Overall Design: case-control comparisons
ORGANISM(S): Homo sapiens 
2008-11-29 | E-GEOD-12767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human amniocytes and prenatal chorion villus cells cultured from fetuses with trisomy 13, 18 or 21 and those from healthy controls
Background: Among full autosomal trisomies, only trisomies of chromosome 21 (Down syndrome, DS), 18 (Edward syndrome, ES) and 13 (Patau syndrome, PS) are compatible with postnatal survival. But the mechanisms, how a supernumerary chromosome disrupts the normal development and causes specific phenoty...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6283 | biostudies-arrayexpress
ProteomicsHuman chorionic villus proteome
We evaluated the effect of the different solubilization techniques on the reproducibility and width of the chorionic proteome characterized using bottom-up proteomics: SDS-based solubilization coupled with in-gel protein digestion after applying self-named 1DE gel-concentration procedure (SDS-PAGE w...
ORGANISM(S): Homo sapiens (Human) 
2022-06-17 | PXD024759 | Pride
Human Chorionic villus Trophoblast Lc-ms/ms 
TranscriptomicsArray-based DNA-methylation profiling of fetal tissues obtained by routine invasive prenatal testing (chorionic and amniotic samples)
Genome wide DNA methylation profiling of fetal DNA-methylation levels in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples. The Illumina Infinium 27k Human DNA methylation Beadchip was used to determine DNA methylation profiles across approximately 27,578 CpGs in fetal samples. Bisulphite c...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-35327 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Analysis in Human Chorionic Villus and Maternal Blood Cells
Comparative analysis of DNA methylation in 12 human chorionic villus samples and 12 human maternal blood cell samples We performed a genome wide analysis of DNA methylation first trimester CVS samples and gestational age matched MBCs. We analyzed DNA samples obtained from 12 CVS samples and 12 MBC ...
ORGANISM(S): Homo sapiens 
2010-07-31 | E-GEOD-23311 | biostudies-arrayexpress
TranscriptomicsRNA-seq of first-trimester chorionic villus for understanding the maintenance of early gestation as well as pathogenesis in pregnancy-related disorders
Implant failure and insufficient placental development are important causes of female infertility, recurrent miscarriage, and other pregnancy-related problems. A better understanding of gene expression profiling based on high-throughput sequencing technology is important for the study on the develop...
ORGANISM(S): Homo sapiens 
2019-08-31 | E-MTAB-8186 | biostudies-arrayexpress
GenomicsGenetic profiling of first-trimester chorionic villus samples using Affymetrix CytoScan 750K arrays
Genetic profiling of first-trimester chorionic villus samples using Affymetrix CytoScan 750K arrays
PRJNA1312802 | ENA
Methylation profilingDNA Methylation Analysis in Human Chorionic Villus and Maternal Blood Cells
Comparative analysis of DNA methylation in 12 human chorionic villus samples and 12 human maternal blood cell samples
ORGANISM(S): Homo sapiens 
2010-07-31 | GSE23311 | GEO
TranscriptomicsChorionic villus sampling (CVS) microarray in preeclampsia
4 chorionic villus sampling specimens in pregnancies destined for preeclampsia and 8 matched controls were analyzed 36 genes were differentially expressed using J5 score and prediction modeling in caGEDA computer program Keywords: snap frozen, banked CVS specimens with known pregnancy outcomes revea...
ORGANISM(S): Homo sapiens 
2008-11-25 | GSE12767 | GEO
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