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TranscriptomicsMicroarray analysis of WT and Tfap4-KO CD8 T cells during early activation
Gene expression of Tfap4–/– and WT CD8+ T cells were compared after activation with anti-CD3 and anti-CD28 antibodies in vitro or with Listeria monocytogenes infection in vivo For in vitro activation, naive CD8+ T cells were purified from WT and Tfap4–/– mice and activated with anti-CD3 and ...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58078 | biostudies-arrayexpress
TranscriptomicsDefining AP4- and MYC-regulated gene expression programs in germinal center B cells during cyclic re-entry
B cells diversify and affinity-mature their antigen receptor repertoire in germinal centers (GC). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions sustain the subsequent proliferative program of selected B cells. H...
ORGANISM(S): Mus musculus 
2016-08-23 | E-GEOD-80669 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Cbfb-deficient LSK and GMP
Runx/Cbfb heterodimers play important roles in the development of hematopoietic cells in mouse embryos and adults. In order to identify genes that are regulated by Runx/Cbfb, we purified Lin– c-kit+ Sca1+ (LSK) cells and Lin– c-kit+ Sca1– CD16/32+ (GMP) cells from Vav1-iCre x Cbfb(F/F) and Vav1-iCre...
ORGANISM(S): Mus musculus 
2014-04-05 | E-GEOD-55227 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Myc, AP4, and phosphorylated RNA polymerase II binding in activated CD8 T cells by ChIP sequencing
The trasncription factor cMyc is an essential transcription factor that establishes a metabolically active and proliferative state in T cells after antigen priming. However, its expression is transient. To date, it remains unknown how T cell activation is maintained after cMyc down-regulation. Here,...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58075 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cMyc-deficient CD8 T cells retrovirally overexpressing cMyc or AP4
To determine functional overlap between cMyc and AP4 in CD8+ T cell priming, we retrovirally expressed cMyc or AP4 in cMyc-deficient CD8+ T cells and examined gene expression after activation. Naive CD8+ T cells from Myc conditional knockout mice with a tamoxifen inducible Cre transgene were retrovi...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58079 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the effects of IL-2 signaling on in vitro activated WT CD8 T cells
Interleukin 2 (IL-2) promotes proliferation and differentiation of CD8+ T cells in vitro and in vivo. To define gene expression regulated by IL-2, we purified naive CD8+ T cells, activated them for 2 days followed by treatment with recombinant IL-2 or with neutralizing antibody against IL-2 and com...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58077 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of WT and Tfap4–/– OT-I cells activated by Listeria monocytogenes expressing ovalbumin
Gene expression of Tfap4–/– and WT OT-I T cells were compared 4 or 6 days after activation with Listeria monocytogenes infection in vivo with the ERCC spike-in RNA control. Naive CD8+ T cells from Tfap4–/– OT-I or control WT OT-I TCR transgenice mice were adoptively transferred to congenic host mice...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58076 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of Gastrodia elata (Orchidaceae) in response to fungus symbiosis to identify gastrodin biosynthesis-related genes
Gastrodia elata Blume (Orchidaceae) is an important Chinese medicine with several functional components. In the life cycle of G. elata, the orchid develops a symbiotic relationship with two compatible mycorrhizal fungi Mycena spp. and Armillaria mellea during seed germination to form vegetative prop...
ORGANISM(S): Gastrodia elata 
2016-08-23 | E-GEOD-73633 | biostudies-arrayexpress
UnknownComparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry.
Not available
S-EPMC10896194 | biostudies-literature
MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
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