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TranscriptomicsGenomic profile of foamy and non-foamy granuloma macrophages from fat-fed ApoE null mice or control mice fed a normal diet
Formation of foam cell macrophages (FCMs), which sequester extracellular modified lipids, is a key event in atherosclerosis. How lipid loading affects macrophage phenotype is controversial, with evidence suggesting either pro- or anti-inflammatory consequences. To investigate this further, we compar...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-70126 | biostudies-arrayexpress
TranscriptomicsThe genetic architecture of the genome-wide transcriptional response to ER stress in the mouse
Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell. ER stress is a primary cause and a modifier of many human diseases. A first ste...
ORGANISM(S): Mus musculus 
2014-12-02 | E-GEOD-63756 | biostudies-arrayexpress
MetabolomicsComprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart
The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet a...
2015-11-17 | MTBLS173 | MetaboLights
UnknownRandomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer.
Not available
S-EPMC3532391 | biostudies-literature
UnknownPostoperative rehospitalization in older surgical patients: an age-stratified analysis.
Not available
S-EPMC10286398 | biostudies-literature
TranscriptomicsTranscription profiling of soleus muscle from lean and obese Zucker rats following exercise training
Endurance exercise training has been shown to decrease whole-body and skeletal muscle insulin resistance and increase glucose tolerance in conditions of both pre-diabetes and overt type 2 diabetes. However, the adaptive responses in skeletal muscle at the molecular and genetic level for these benef...
ORGANISM(S): Rattus norvegicus 
2009-11-16 | E-TABM-213 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 5 strains of rat: WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA)
5 strains of rat, WKY, spontaneously hypertensive rat (SHR) and 3 reciprocal congenic strains (WconSA, SconSA and SISA) were used to generate expression data across the genome using the Affymetrix rat genome chip set comprising the 230 A and 230 B chips. 5 animals from each strain were used. Express...
ORGANISM(S): Rattus norvegicus 
2007-04-16 | E-TABM-45 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain, kidney, stomach, liver, and salivary tissues of perinatal ERRI? null and wild type mice ERRIalpha Regulates Cardiac, Gastric and Renal Potassium Homeostasis
Genomic analysis of expression in brain, kidney, stomach, liver, and salivary tissues of perinatal ERRγ null and wild type mice. Experiment Overall Design: Total RNA was extracted from brain, kidney, stomach, liver, and salivary tissues of perinatal ERRγ null and wild type mice and hybridized to A...
ORGANISM(S): Mus musculus 
2009-11-14 | E-GEOD-18896 | biostudies-arrayexpress
TranscriptomicsAcute hepatic transcriptional response in male mice following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male B6C3F1 mice were exposed to four doses of benzo(a)pyrene or vehicle contr...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-43633 | biostudies-arrayexpress
UnknownTravertine crystal growth ripples record the hydraulic history of ancient Rome's Anio Novus aqueduct.
Not available
S-EPMC8786873 | biostudies-literature
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