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MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
MetabolomicsCollagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...
2015-11-04 | MTBLS243 | MetaboLights
GenomicsMus musculus strain:CBA/J
Mus musculus strain:CBA/J Raw sequence reads
PRJNA1241294 | ENA
TranscriptomicsIdentification of candidate susceptibility and resistance genes of mice infected with Streptococcus suis type 2
There were four groups:control A/J mice;control B6 mice;SS2-infected A/J mice;SS2-infected B6 mice.The RNA samples of four groups were sent to Biostar Genechip Inc. (Shanghai, China) for microarray hybridization. The pooled RNA sample from each group was hybridized to one Illumina mouse Genome Beadc...
ORGANISM(S): Mus Musculus 
2012-02-09 | E-MTAB-745 | biostudies-arrayexpress
TranscriptomicsGene expression in soleus muscle of mouse inbred strains LG/J and SM/J
Variability in muscle mass significantly impacts energy expenditure, influencing preponderance to obesity and recently it has been reported that there is a positive association between muscle mass and longevity in older adults. Muscle fibre cross-sectional area (CSA) and proportion of different fibr...
ORGANISM(S): Mus musculus 
2017-01-23 | E-MTAB-5290 | biostudies-arrayexpress
TranscriptomicsDifferential expression of genes in pancreatic islets from high fat fed AKR/J and C57Bl/6J
Increased fat intake is associated with obesity and insulin resistance. In some individuals, a failure of pancreatic b-cells to increase insulin production in response to the high demands of obesity leads to diabetes. We sought to determine whether the impaired b- cell adaptation in obesity is assoc...
ORGANISM(S): Mus musculus 
2008-02-28 | GSE10639 | GEO
GenomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
PRJEB32450 | ENA
TranscriptomicsTranscriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in vitro
Hepatic stellate cells are involved in the development of hepatic fibrosis. We here perform transcriptional profiling of hepatic stellate cells (HSCs) isolated from Western diet/high fructose-fed C57BL6/J mice, carbon tretrachloride (CCl4)-treated C57BL6/J mice, and of murine HSCs differentiated in ...
ORGANISM(S): Mus musculus 
2019-04-07 | E-MTAB-7054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse AKR/J and C57Bl/6J strain pancreatic islets from high fat fed
Increased fat intake is associated with obesity and insulin resistance. In some individuals, a failure of pancreatic b-cells to increase insulin production in response to the high demands of obesity leads to diabetes. We sought to determine whether the impaired b- cell adaptation in obesity is assoc...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice with hromosome substitution from A/J strain vs parental strains, and acute lung injury following ozone exposure
Mice with a chromosome substitution from A/J strain were compared to parental strains, and acute lung injury following ozone exposure was measured. The candidate gene identified by microarray and genome-wide scans was tested in knockout and pharmacologically altered mice.
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-17 | biostudies-arrayexpress
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