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GenomicsGenome-wide maps of NME2 in A549 lung adenocarcinoma cells.
It is widely believed that reorganization of nucleosomes result in availability of transcription factor (TF) binding sites for eukaryotic gene regulation. Recent findings also show TFs induced during physiological perturbations can alter nucleosome occupancy to facilitate DNA binding. Although, thes...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40300 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in A549 cells before/after NME2 induction
Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40363 | biostudies-arrayexpress
TranscriptomicsDecreased TFR/TFH ratio in SIV-infected rhesus macaques may contribute to accumulation of TFH cells in chronic infection
T follicular helper cells (TFH) are critical for the development and maintenance of germinal centers (GC) and humoral immune responses. During chronic HIV/SIV infection TFH accumulate, possibly as a result of antigen persistence. The HIV/SIV-associated TFH expansion may also reflect lack of regulati...
ORGANISM(S): Macaca mulatta 
2015-09-02 | E-GEOD-69756 | biostudies-arrayexpress
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