Sort   by:  
 Page size 
TranscriptomicsOncogenic Ras inhibits IRF1 to promote viral oncolysis
Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-mediated antiviral responses are known to be the major mechanisms underlying viral oncolysis. Previous...
ORGANISM(S): Mus musculus 
2014-11-13 | E-GEOD-49469 | biostudies-arrayexpress
TranscriptomicsSuppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells
Certain oncolytic viruses exploit activated Ras signalling in order to replicate in cancer cells. Constitutive activation of the Ras/MEK pathway is known to suppress the effectiveness of the interferon (IFN) antiviral response, which may contribute to Ras-dependent viral oncolysis. Here, we identifi...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-31019 | biostudies-arrayexpress
ProteomicsThe CD24 receptor induces changes to the surface protein composition of B cell microvesicles with variable effects on their RNA and protein cargo
The CD24 cell surface receptor promotes apoptosis in developing B cells, and we recently found that it induces B cells to release plasma membrane-derived, CD24-bearing microvesicles (MVs). Here we have performed a systematic characterization of B cell MVs released from WEHI-231 B lymphoma cells in r...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-01 | PXD005919 | Pride
Cd24 Microvesicle Extracellular microvesicles Proteomics B lymphocyte Mitochondria 
Sort   by:  
 Page size