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TranscriptomicsExpression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter
The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV node-specific reporter mouse to gain insight into the gene programs determining the forma...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-13614 | biostudies-arrayexpress
GenomicsGenome-wide occupancy profile of Tbx3, Gata4, Nkx2-5 and p300 in adult mouse whole heart
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous ge...
ORGANISM(S): Mus musculus 
2012-06-22 | E-GEOD-35151 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of induced expression of TBX3 in the atrial appendage of the heart and controls.
to study the effect of induced expression of TBX3 within the atrium of the heart Background: Treatment of congenital or acquired disorders of the sinus node or atrioventricular node requires insight into the molecular mechanisms for the development and homeostasis of these pacemaker tissues. In the ...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-31969 | biostudies-arrayexpress
TranscriptomicsTbx2 and Tbx3 impose nodal phenotype and induce cushion formation in the atrioventricular canal
Rationale: A critical step in heart development is the coordinated formation of nodal myocardium and cushion tissue from the atrioventricular canal (AVC). After its specification, the myocardium of the AVC aligns the chambers, forms the AV node, and induces the formation of the mesenchymal AV cushio...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-10318 | biostudies-arrayexpress
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