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TranscriptomicsGlobal genomic mapping, in Saccharomyces cerevisiae, of new suppressor alleles of the RNA polymerase I subunit rpa49 deletion.
In the yeast saccharoryces cerevisiae, RPA49 full-deletion mutants show a strong growth defect at 30°C and are unable to grow at 25°C. However, spontaneous suppressors that restore growth at 25°C are observed. We attend to identified new suppressor alleles after UV treatment. To mapped the genomic l...
ORGANISM(S): Saccharomyces cerevisiae 
2019-12-31 | E-MTAB-7831 | biostudies-arrayexpress
TranscriptomicsComparative genomic profile of human brain microvascular endothelial cells upon TWEAK or TNFα stimulation at 3h, 12h, and 24h
The molecular mechanisms playing a role in TWEAK versus TNFɑ signaling on cerebral microvascular endothelial cells are not well defined. Therefore, we aimed to identify gene expression changes in cultures of human brain microvascular endothelial cells (hCMEC/D3) to address changes initiated by TWEAK...
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12222 | biostudies-arrayexpress
GenomicsGenomic binding of Pol III transcription machinery and relationship with TFIIS distribution in mouse embryonic stem cells
RNA polymerase (RNA Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of RNA Pol III and its associated transcription factors on the genome of mouse...
ORGANISM(S): Mus musculus 
2011-09-16 | E-MTAB-767 | biostudies-arrayexpress
TranscriptomicsHost microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses
In this study, we performed a miRNA global profiling in human lung epithelial cells (A549) infected by two different subtypes of human influenza A viruses (H1N1 and H3N2). A549 cells were either mock-infected or infected at a multiplicity of infection (MOI) of 1 with H1N1 or H3N2 viruses, and total ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42003 | biostudies-arrayexpress
MetabolomicsHigh metabolic variation for seaweeds in response to environmental changes: a case study of the brown algae Lobophora in coral reefs
In the marine environment, macroalgae face changing environmental conditions and some species are known for their high capacity to adapt to the new factors of their ecological niche. Some macroalgal metabolites play diverse ecological functions and belong to the adaptive traits of such species. Beca...
2019-09-02 | MTBLS707 | MetaboLights
TranscriptomicsPituitary tumors contain a (CD31¯/CD45¯ purified) side population with 'tumor stem cell'-associated characteristics [set 2]
Pituitary adenomas cause significant endocrine and mass-related morbidity. Not much is known about mechanisms underlying pituitary tumor pathogenesis. We searched for a side population (SP) in pituitary tumor, representing cells with high efflux capacity and potentially enriching for cancer/tumor st...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-62870 | biostudies-arrayexpress
ProteomicsMS-CETSA discovery of target engagement by Darapladib
We used the lysate MS-CETSA Isothermal Dose-Response (ITDR) protocol to discover the interactions of Darapladib with proteins in Plasmodium falciparum and human red blood cells proteomes.
ORGANISM(S): Plasmodium Falciparum 
2022-05-18 | PXD029803 | JPOST Repository
TranscriptomicsMetaMeta
Investigate the difference between highly metastatic cells vs parental low metastatic cells.
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-2656 | biostudies-arrayexpress
TranscriptomicsPituitary tumors contain a side population with 'tumor stem cell'-associated characteristics [set 1]
Pituitary adenomas cause significant endocrine and mass-related morbidity. Not much is known about mechanisms underlying pituitary tumor pathogenesis.We searched for a side population (SP) in pituitary tumor, representing cells with high efflux capacity and potentially enriching for cancer/tumor ste...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-62866 | biostudies-arrayexpress
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
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