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MetabolomicsIDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therapeutic strategies. Using proteomics and transcriptomic pro...

2026-01-14 | MTBLS11531 | MetaboLights
GenomicsFrequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n¼54), genome/exome (n¼44) and transcriptome (n¼69) sequencing of pulmonary...
EGAS00001000650 | EGA
GenomicsDriver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction, we sequenced the exomes of 48 paediatric GBM samp...
EGAS00001000226 | EGA
ProteomicsAP-MS MudPIT run of Ino80 complex
File name explanation: Sc_Ino80_TAP_V2_P1_Ti_101: Sc = Saccharomyces cerevisiae (specie) Ino80 = bait protein TAP = tag V2 = lab instrument name(Velos_Elite2) P1 = biological replicate 1 Ti = LysC+Trypsin digestion 101 = MudPIT run 1 from 1st technical replicate
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-01-28 | MSV000079018 | MassIVE
GenomicsExtensive Chromatin Remodeling and Establishment of Transcription Factor 'Hotspots' during Early Adipogenesis
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer binding protein (C/EBP) family members are key regulators of this process. We have employ...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-27826 | biostudies-arrayexpress
ProteomicsBAF60/SWP73 Subunits Define Subclasses of SWI/SNF Chromatin Remodelling Complexes in Arabidopsis
• Evolutionarily conserved SWI-SNF ATP-dependent chromatin remodeling complexes (CRCs) change nucleosome positioning and chromatin states, affecting gene expression to regulate important regulatory processes controlling such as proper development and hormonal signalling pathways. • In our study we...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-04-15 | PXD056187 | Pride
Hormonal signalling Metabolome Chromatin remodelling complexes Swp73/baf60 Swi/snf 
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (ChIP-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53583 | biostudies-arrayexpress
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (Dnase-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53584 | biostudies-arrayexpress
GenomicsGenomic analyses of gynecologic carcinosarcomas reveal frequent mutations in chromatin remodeling genes
Malignant Mixed Müllerian Tumors, also known as carcinosarcomas, are rare tumors of gynecological origin. Here we perform whole exome analyses of 22 tumors using massively parallel sequencing to determine the mutational landscape of this tumor type. On average, we identify 43 mutations per tumor, ...
EGAS00001000941 | EGA
TranscriptomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions [Affymetrix]
Expression data from 3134 mouse mammary epithelial cell line -/+ Tet-inducible chromatin remodeler mutant variants ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-66544 | biostudies-arrayexpress
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