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TranscriptomicsGenotyping of human chromosomal instability patterns discriminates rectal adenomas from carcinomas
Total mesorectal excision (TME) is the standard treatment for rectal cancer, while transanal endoscopic microsurgery (TEM) is a recently introduced surgical approach for the treatment of rectal adenomas. Incorrect preoperative staging before TEM is a problem. To identify genetic changes that migh...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-7946 | biostudies-arrayexpress
TranscriptomicsApplication of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions
Chromosomal instability is central to the process of carcinogenesis. The detection of somatic chromosomal alterations in small premalignant lesions genome-wide remains challenging since sample heterogeneity dilutes the aberrant cell information. We introduced an analytic metric termed "delta-θ&...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-43168 | biostudies-arrayexpress
TranscriptomicsThe gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome
Recently, expression profiling of breast carcinomas has revealed gene signatures that predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. Measurement of the degree of genomic instability provides a very similar stratification of prognostic groups. We therefore...
ORGANISM(S): Homo sapiens 
2009-11-30 | E-GEOD-11901 | biostudies-arrayexpress
TranscriptomicsCancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo
Chromosomal instability (CIN) is a known hallmark of cancer, yet it also imposes stresses that reduce cellular fitness. In order to bridge the gap in knowledge on how cancer cells adapt to CIN-imposed stresses, we performed genome-wide transposon mutagenesis screen. Samples deposited in this databas...
ORGANISM(S): Mus musculus 
2023-11-30 | E-MTAB-11247 | biostudies-arrayexpress
TranscriptomicsImmortalization capacity of HPV types is inversely related to chromosomal instability in immortal descendants.
Human papillomavirus (HPV) induced immortalization of human foreskin keratinocytes (HFK) is a two-step process, including 1) the bypass of replicative senescence and acquisition of an extended lifespan, and 2) the outgrowth of immortal cells. Our previous study showed that the immortalization capaci...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-72063 | biostudies-arrayexpress
ProteomicsChromosomal instability adaptation dependencies confer unique targetable vulnerabilities in therapy refractory lethal prostate cancer
Chromosomal instability (CIN), an ongoing rate of chromosome missegregation during mitosis, is a defining feature of cancer. However, high chromosomal aberrations are detrimental for cell fitness. Here we investigated mechanisms allowing lethal prostate cancer (PCa) to tolerate and survive increasin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD028271 | Pride
Mastl expression Chromosomal instability 
TranscriptomicsA new classification of chromosome instability (CIN) phenotype, CIN-high and CIN-low
Samples were taken from colorectal cancers in surgically resected specimens in 35 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be u...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-30540 | biostudies-arrayexpress
GenomicsChromosomal instability and genomic alterations in Cholangiocarcinoma
Chromosomal instability and genomic alterations in Cholangiocarcinoma
PRJEB87878 | ENA
UnknownModest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability.
Not available
S-EPMC10500341 | biostudies-literature
ProteomicsKSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
ORGANISM(S): Homo Sapiens (human) 
2020-12-15 | PXD010107 | JPOST Repository
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