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TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA
Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which it...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-12734 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia cells treated with valproic acid
Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis ...
ORGANISM(S): Homo sapiens 
2009-09-17 | E-GEOD-14973 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
ProteomicsAging-related proteome alterations in B cells may predispose for chronic lymphocytic leukemia - nuclear proteins of elderly B cells
Chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults, is still incurable despite the development of novel therapeutic strategies. This reflects the incomplete understanding of the pathophysiology of this disease. In order to get more detailed insights into CLL development, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082941 | MassIVE
GenomicsChromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
2016-06-26 | E-GEOD-81274 | biostudies-arrayexpress
TranscriptomicsMiR-181b is a biomarker of disease progression in Chronic Lymphocytic Leukemia
We studied the value of the microRNAs as a signature for Chronic lymphocytic leukemia (CLL) patients with specific chromosomal abnormalities. We found that MiR-181b is abiomarker of disease progression in Chronic Lymphocytic Leukemia
ORGANISM(S): Homo sapiens 
2011-09-22 | E-MTAB-683 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Chronic Lymphocytic Leukemia samples
Microarray technology was used to predict the outcome of Chronic Lymphocytic Leukemia
ORGANISM(S): Homo sapiens 
2007-09-04 | E-TABM-80 | biostudies-arrayexpress
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immunoglobulin mutation genotype in B Cell chronic lymphocytic leukaemia
The Journal of Experimental Medicine, Volume 194, Number 11, December 3, 2001 1639-1648 Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia Andreas Rosenwald1, Ash A. Alizadeh2, George Widhopf5, Richard Simon6, R. Eric Davis1, Xin Yu1, ...
ORGANISM(S): Homo sapiens 
2005-06-29 | E-SMDB-1002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Chronic Lymphocytic Leukemia cells with mutated and unmutated IGHV
High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival
ORGANISM(S): Homo sapiens 
2009-09-17 | E-TABM-696 | biostudies-arrayexpress
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