Chronic lymphocytic leukemia

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Unknown (3051)
Transcriptomics (964)
Genomics (867)
Proteomics (81)
Clinical (61)
Methylation profiling (18)
Other (16)
Genomic (14)
Models (5)
Metabolomics (1)

Organisms

Homo sapiens (1030)
Mus musculus (238)
Rattus norvegicus (4)
Betapolyomavirus macacae (3)
human gammaherpesvirus 4 (3)
JC polyomavirus (3)
Betapolyomavirus hominis (3)
Human alphaherpesvirus 1 (3)
Human gammaherpesvirus 8 (3)
Human immunodeficiency virus 1 (3)
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Herpesvirus saimiri (strain 11) (2)
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Macacine alphaherpesvirus 1 (2)
Human alphaherpesvirus 2 (2)
human gut metagenome (1)
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Nicotiana tabacum (1)
Populus tremula x Populus alba (1)
Arabidopsis thaliana (1)
Murid gammaherpesvirus 4 (1)
Murid betaherpesvirus 1 (1)
synthetic construct (1)

Organisms

Homo sapiens (403)
Mus musculus (67)
viral metagenome (1)

Repository

biostudies-arrayexpress (712)
ENA (582)
geo (410)
EGA (156)
pride (67)
dbGaP (14)
ExpressionAtlas (10)
MassIVE (8)
Cell Collective (3)
BioModels (2)
EVA (2)
MetaboLights (1)
PanoramaPublic (1)
PAXDB (1)

Tissue

B cell (37)
Blood (18)
Cell culture (12)
Blood cell (7)
Peripheral blood mononuclear cell (7)
Primary cell (5)
Kidney (3)
B-lymphocyte (3)
Spleen (3)
Stromal cell (3)
Uterine cervix (2)
Breast (2)
Esophagus (2)
Mouth mucosa (2)
Large intestine (2)
Stomach (2)
Pancreas (2)
Ovary (2)
Uterus (2)
Skeletal muscle tissue (2)
Urinary bladder (2)
Skin (2)
Prostate gland (2)
Thyroid gland (2)
Brain (2)
Lung (2)
Liver (2)
B-cell chronic lymphocytic leukemia cell (2)
Blood plasma (2)
Cell suspension culture (2)

Disease

Chronic lymphocytic leukemia (52)
Lymphoma (10)
Normal (9)
Breast adenocarcinoma (5)
Renal cell carcinoma (3)
Pancreatic adenocarcinoma (3)
Follicular thyroid carcinoma (3)
Cervical adenocarcinoma (3)
Gastric adenocarcinoma (3)
Hepatocellular carcinoma (3)
Bladder transitional cell carcinoma (3)
Invasive lobular carcinoma (3)
Head and neck squamous cell carcinoma (3)
Squamous cell lung carcinoma (3)
Cervical squamous cell carcinoma (3)
Ovarian adenocarcinoma (3)
Melanoma (3)
Cholangiocarcinoma (3)
Esophageal adenocarcinoma (3)
Lung adenocarcinoma (3)
Multiple myeloma (2)
Glioblastoma multiforme (2)
Colorectal adenocarcinoma (2)
Chromophobe renal cell carcinoma (2)
Prostate adenocarcinoma (2)
Sarcoma (2)
Endometrial adenocarcinoma (2)
Glioma (2)
B-cell non-Hodgkin lymphoma (2)
B cell chronic lymphocytic leukemia (1)

Technology Type

Mass Spectrometry (67)
Shotgun proteomics (42)
Bottom-up proteomics (10)
SWATH MS (6)
Affinity purification coupled with mass spectrometry proteomics (5)
Data-dependent acquisition (5)
Gel-based experiment (4)
Illumina HiSeq 2500 (3)
Illumina HiSeq 2500, ILLUMINA (2)
ILLUMINA, Illumina HiSeq 2000 (2)
Data-independent acquisition (2)
Immunopeptidomics (2)
Illumina CytoSNP, Illumina HumanOmni2.5, ILLUMINA, Illumina 450k, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 2000, Illumina MiSeq (1)
Illumina MiSeq, ILLUMINA (1)
Illumina HiSeq 3000 (1)
Illumina Genome Analyzer IIx, Illumina Genome Analyzer II, Affymetrix U219 (1)
Affymetrix U219, Illumina HumanMethylation450, Illumina Genome Analyzer IIx (1)
Illumina Genome Analyzer II, Affymetrix snp 6.0, Illumina Genome Analyzer IIx, GPL570, Affymetrix GeneChip Human Genome U133 plus 2.0 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, ILLUMINA (1)
Mass spectrometry (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
HDMSE (1)
Proteogenomics (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (21)
Illumina HiSeq 2000 (11)
NextSeq 500 (9)
Illumina HiSeq 2500 (6)
Illumina HiSeq 4000 (5)
Axon GenePix 4000B scanner (2)
Axon- GenePix4000B (2)
ScanArray 4000XL [PerkinElmer] (2)
Scanning hardware (2)
Illumina MiSeq (2)
NextSeq 550 (2)
Illumina HiSeq 3000 (2)
Affymetrix GCS 3000 (1)
GeneChip® Pico Kit (Affymetrix) (1)
Affymetrix Clariom™ S (400 Format) (1)
NextSeq 500, 75 bp single end lane (1)
MacBook Pro 64Gb RAM; 16-core (1)
Qubit 2.0 Fluorometer; Agilent TapeStation 4200 (1)
Microarray scanner system (1)
Agilent SureScan High Resolution scanner (1)
Covaris S2 (1)
DNA Microarray Scanner (Model G2505C, Agilent Technologies) (1)
GenePix 4000B [Axon] (1)
454 GS FLX (1)
Illumina BeadScan (1)
Not applicable (1)
GCS3000 (1)
Affymetrix HG-U133 Plus 2.0, fluidics sstation 450 (1)
Affymetrix Fluidics Station (1)
GeneChip Scanner 3000 7G (1)

Publication Date

2013 (108)
2008 (108)
2015 (86)
2009 (85)
2011 (80)
2014 (77)
2016 (66)
2012 (61)
2022 (57)
2021 (56)
2010 (52)
2026 (51)
2025 (48)
2024 (46)
2023 (44)
2020 (36)
2017 (34)
2019 (33)
2007 (31)
2018 (28)
2005 (13)
2006 (7)
2004 (5)

UNIPROT ID/AC

1433B_HUMAN (1)
1433E_HUMAN (1)
1433F_HUMAN (1)
1433G_HUMAN (1)
1433S_HUMAN (1)
1433T_HUMAN (1)
1433Z_HUMAN (1)
2A5A_HUMAN (1)
2A5D_HUMAN (1)
2A5E_HUMAN (1)
2A5G_HUMAN (1)
2AAA_HUMAN (1)
2AAB_HUMAN (1)
2ABA_HUMAN (1)
2ABB_HUMAN (1)
2ABD_HUMAN (1)
2ABG_HUMAN (1)
3BP1_HUMAN (1)
3BP2_HUMAN (1)
3BP5L_HUMAN (1)
3HAO_HUMAN (1)
3HIDH_HUMAN (1)
3MG_HUMAN (1)
4EBP1_HUMAN (1)
4EBP2_HUMAN (1)
4ET_HUMAN (1)
4F2_HUMAN (1)
5HT2A_HUMAN (1)
5HT4R_HUMAN (1)
5NT3A_HUMAN (1)

CHEBI ID

CHEBI:4027 (1)
CHEBI:52334 (1)
CHEBI:8227 (1)
CHEBI:21884 (1)
CHEBI:131623 (1)
CHEBI:165213 (1)
CHEBI:166735 (1)
CHEBI:39390 (1)
CHEBI:18048 (1)
CHEBI:3087 (1)
CHEBI:32321 (1)
CHEBI:74957 (1)
CHEBI:76792 (1)
CHEBI:32357 (1)
CHEBI:143096 (1)
CHEBI:9908 (1)
CHEBI:52617 (1)
CHEBI:15430 (1)
CHEBI:141030 (1)
CHEBI:143095 (1)
CHEBI:95115 (1)
CHEBI:28374 (1)
CHEBI:133343 (1)
CHEBI:4630 (1)
CHEBI:33946 (1)
CHEBI:90483 (1)
CHEBI:65004 (1)
CHEBI:19274 (1)
CHEBI:27082 (1)
CHEBI:137440 (1)

Metabolite Name

Ursolic acid (1)
Ursocholate (1)
Tyrosol (1)
Soyasaponin III (1)
Soyasaponin II (1)
Soyasaponin I (1)
Sinensetin (1)
Sinapate (1)
Rhodamine B (1)
Pinosylvin monomethylether (1)
Pinosylvin (1)
P-hydroxybenzaldehyde (1)
Phenylacetylphenylalanine (1)
P-cresol (1)
N-propionylmethionine (1)
N-myristoyltaurine* (1)
N-acetylmuramate (1)
N-acetylglucosamine 6-sulfate (1)
N6-formyllysine (1)
N6-carboxyethyllysine (1)
Mevalonolactone (1)
Mevalonate (1)
Methyl-4-hydroxybenzoate (1)
Maltol (1)
Malonylgenistin (1)
Lithocholate (1)
Isohyodeoxycholate (1)
Glycitein (1)
Glucosamine 6-sulfate (1)
Galacturonate (1)

First Public Date

2014 (113)
2024 (57)
2022 (53)
2021 (50)
2023 (42)
2020 (42)
2026 (39)
2025 (37)
2015 (34)
2019 (31)
2018 (27)
2016 (24)
2017 (18)
2013 (15)

Modelling Approach

Ordinary differential equation model (2)

Study status

Completed (36)
Terminated (13)
Active, not recruiting (4)
Recruiting (4)
Withdrawn (3)
Not yet recruiting (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (8)
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany (3)
Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany (2)
Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany (2)
Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France (2)
Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland (2)
University of Nebraska Medical Center (2)
1 Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic 2 Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic (1)
Academia Sinica, Institute of Biological Chemistry (1)
CDSS Bioanalytical Facility, Liverpool Shared Research Facilities, University of Liverpool (1)
CNIO (1)
Cancer Sciences, Faculty of Medicine, University of Southampton, UK (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany (1)
Clinical and Experimental Sciences Unit, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK (1)
Dana-Farber Cancer Institute (1)
Department of Chemical & Systems Biology, Stanford University, USA (1)
Department of Medicine and General Service of Cytometry, Cancer Research Centre-IBMCC, IBSAL. University of Salamanca-CSIC, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain (1)
Department of Microbiology and Immunology, The Scripps Research Institute; Jupiter, FL, USA (1)
Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory (1)
Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany (1)
Dept. Oncology Pathology, Karolinska Institutet, and Scilifelab, Stockholm, Sweden (1)
Division of Blood Cells and Blood Cancer The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville Victoria, Australia, 3050 (1)
Division of Hematology, Department of Medicine, Stanford University School of Medicine Department of Chemistry, Northwestern University (1)
Finley and Gygi lab - Cell Biology Department - Harvard Medical School (1)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (1)
Head of Proteomics CRUK Cambridge Institute Cambridge University Robinson Way Cambridge CB2 0RE UK Email: clive.d’santos@cruk.cam.ac.uk Phone: +44 1223 769677 (1)
Head of the Department, Proteomics Core (1)
Institut Pasteur de Montevideo (1)
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland (1)
Institute of Biological Chemistry, Academia Sinica (1)

Keyword

Fludarabine (10)
Fludarabine phosphate (10)
Rituximab (9)
Mycophenolic Acid (8)
Cyclosporine (8)
Cyclosporins (8)
Antibodies, Monoclonal (8)
Cyclophosphamide (7)
Antibodies (7)
Etoposide (6)
Etoposide phosphate (6)
Immunoglobulins (6)
Lenalidomide (5)
Antineoplastic Agents, Immunological (5)
Tacrolimus (4)
Vorinostat (4)
Bendamustine Hydrochloride (3)
Busulfan (3)
Gemcitabine (3)
Histone Deacetylase Inhibitors (2)
Bortezomib (2)
Vincristine (2)
Doxorubicin (2)
Liposomal doxorubicin (2)
Methotrexate (2)
Dexamethasone (2)
Ipilimumab (2)
Romidepsin (2)
Irinotecan (2)
Belinostat (1)

IsPrivate

False (2)

Submitter Keywords

Immuno-oncology (2)

Modification

N6 (1)
N6-dimethyl-L-lysine (1)
Not available (1)

Study type

Transcription profiling by array (480)
Comparative genomic hybridization by array (43)
RNA-seq of coding RNA (41)
Genotyping by array (23)
ChIP-seq (21)
Methylation profiling by array (12)
MicroRNA profiling by array (11)
DNA-seq (9)
Methylation profiling by high throughput sequencing (7)
Unknown experiment type (6)
Other (6)
RNA-seq of coding RNA from single cells (6)
ChIP-chip by tiling array (4)
RNA-seq of total RNA (4)
Animal - One-color microarray (3)
RNAi profiling by array (3)
ChIP-chip by array (3)
ATAC-seq (3)
RIP-seq (3)
Transcription profiling by SAGE (2)
Human - Two-color microarray (2)
Cell line - One-color microarray (2)
Transcription profiling by RT-PCR (2)
4C (2)
Proteomic profiling by array (2)
RNA-seq of non coding RNA (2)
RNA-seq of non coding RNA from single cells (1)
Animal - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)

Release Date

2022 (345)
2021 (321)
2023 (277)
2025 (233)
2020 (231)
2019 (225)
2016 (224)
2018 (218)
2015 (217)
2024 (214)
2017 (198)
2014 (196)
2013 (177)
2011 (120)
2008 (119)
2012 (112)
2010 (110)
2009 (104)
2007 (41)
2026 (35)
2005 (19)
2006 (13)
2004 (8)
2002 (2)
1997 (2)
2001 (1)
1998 (1)

Location

United States (58)
Italy (5)
Canada (4)
Germany (2)
India (1)
South Korea (1)
Australia (1)
France (1)

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Transcription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA

Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which it...

ORGANISM(S): Homo sapiens

2009-04-25 | E-GEOD-12734 | biostudies-arrayexpress

Transcription profiling of human chronic lymphocytic leukemia cells treated with valproic acid

Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis ...

ORGANISM(S): Homo sapiens

2009-09-17 | E-GEOD-14973 | biostudies-arrayexpress

Chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults, is still incurable despite the development of novel therapeutic strategies. This reflects the incomplete understanding of the pathophysiology of this disease. In order to get more detailed insights into CLL development, ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

MSV000082941 | MassIVE

Transcription profiling of human Chronic Lymphocytic Leukemia samples

Microarray technology was used to predict the outcome of Chronic Lymphocytic Leukemia

ORGANISM(S): Homo sapiens

2007-09-04 | E-TABM-80 | biostudies-arrayexpress

MiR-181b is a biomarker of disease progression in Chronic Lymphocytic Leukemia

We studied the value of the microRNAs as a signature for Chronic lymphocytic leukemia (CLL) patients with specific chromosomal abnormalities. We found that MiR-181b is abiomarker of disease progression in Chronic Lymphocytic Leukemia

ORGANISM(S): Homo sapiens

2011-09-22 | E-MTAB-683 | biostudies-arrayexpress

Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20

In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...

ORGANISM(S): Homo sapiens

2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress

Transcription profiling of human CLL - a genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia - super series

This SuperSeries is composed of the following subset Series:; GSE10137: A Genomic Approach to Improve Prognosis and Predict Therapeutic Response in Chronic Lymphocytic Leukemia (Mayo_Ohio); GSE10138: A Genomic Approach to Improve Prognosis and Predict Therapeutic Response in Chronic Lymphocytic Leuk...

ORGANISM(S): Homo sapiens

2009-11-09 | E-GEOD-10139 | biostudies-arrayexpress

Transcription profiling of human chronic lymphocytic leukemia miRNA expression validation

MicroRNA expression profiles can distinguish normal B cells from malignant B cells in chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are associated with known prognostic factors in CLL. We evaluated the microRNa expression profiles of 94 samples of CLL cells for which ...

ORGANISM(S): Homo sapiens

2005-10-27 | E-TABM-42 | biostudies-arrayexpress

Molecular and transcriptional characterization of chromosome 17p loss in chronic lymphocytic leukemia

Distinct genetic abnormalities such as TP53 deletion at 17p13.1, have been identified as having an adverse prognostic relevance in B-cell chronic lymphocytic leukemia (B-CLL). Conventional cytogenetic studies have shown that TP53 deletion in B-CLL is associated predominantly with 17p loss resulting ...

ORGANISM(S): Homo sapiens

2008-11-11 | E-GEOD-11038 | biostudies-arrayexpress

Rodrigues2019 - A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia

THis is a simple ordinary differential equation model describing chemoimmunotherapy of chronic lymphocytic leukemia, including descriptions of the combinatorial effects of chemotherapy and adoptive cellular immunotherapy.

2024-09-02 | BIOMD0000000879 | BioModels

Immuno-oncology

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