Sort   by:  
 Page size 
MetabolomicsUntargeted metabolomics analysis of gingival tissue in patients with severe periodontitis
Periodontitis, as a chronic inflammatory condition, its initiating factor is the plaque biofilm. The inflammation starts in the gingival tissue, if left untreated, may progress to severe periodontitis and cause bone and tooth loss. The purpose of this study was to determine the potential metabolic b...
2026-09-08 | MTBLS8357 | MetaboLights
MetabolomicsIdentification of a discriminative metabolomic fingerprint of potential clinical relevance in saliva of patients with periodontitis using 1H nuclear magnetic resonance (NMR) spectroscopy
Periodontitis is characterized by the loss of the supporting tissues of the teeth in an inflammatory-infectious context. The diagnosis relies on clinical and X-ray examination. Unfortunately, clinical signs of tissue destruction occur late in the disease progression. Therefore, it is mandatory to id...
2018-08-14 | MTBLS524 | MetaboLights
TranscriptomicsRNA-sequencing study of peripheral blood monocytes for chronic periodontitis
We confirmed immune response as the key mechanism and provided solid evidence for novel genes (e.g., FCAR and CUX1) and distinct biological processes (e.g., endocytosis, cytokine production and apoptosis) as potentially new important factors/mechanisms contributing to chronic periodontitis pathogene...
ORGANISM(S): Homo sapiens 
2016-07-16 | E-GEOD-61490 | biostudies-arrayexpress
TranscriptomicsMicroRNAs and their target genes in gingival tissues.
To gain insights into the in vivo function of miRNAs in the context of periodontitis, we examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated their in silico-predicted targets through mRNA profiling using whole-genome microarrays in the same specimens. Eighty-six ...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54710 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Whole Saliva in Chronic Periodontitis
Periodontitis is a chronic inflammatory disease resulting from a dysbiosis of the dental biofilm and a dysregulated host response in susceptible individuals. It is characterized by periodontal attachment destruction, bone resorption, and eventual tooth loss. Salivary biomarkers have been sought to p...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD015024 | Pride
Saliva  periodontitis  periodontal health  proteome  mass spectrometry 
TranscriptomicsTranscription profiling of gingival tissue from patients with periodontitis: Bacterial Correlates of Gingival Gene Expression
We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodontal surgery contributed with a minimum of two interproximal gingival papillae (range 2-4) from a maxillar...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-16134 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from 12 normal and 10 chronic periodontitis patients from site OCI
Microarray methylation (Infinium¨HumanMethylation 450 BeadChip from Illumina) was performed on 12 normal and 10 chronic periodontitis (CP) patients Bisulphite converted DNA from the 22 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-59932 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from 11 normal and 9 chronic periodontitis patients from site USC
Microarray methylation (Infinium®HumanMethylation 450 BeadChip from Illumina) was performed on 11 normal and 9 chronic periodontitis (CP) patients Bisulphite converted DNA from the 20 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
ORGANISM(S): Homo sapiens 
2015-07-29 | E-GEOD-59939 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood neutrophils reveals periodontitis is associated with a type-1 interferon signature
Peripheral blood neutrophils from periodontitis patients exhibit a hyper-reactive and hyper-active phenotype (collectively termed hyper-responsivity) in terms of production of reactive oxygen species (ROS) however the molecular basis for this observation is yet to be determined. Our objectives were ...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12484 | biostudies-arrayexpress
TranscriptomicsAltered gene expressions of leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues
Gene expressions relate to the pathogenesis of periodontitis and have a crucial role in local tissue destruction and susceptibility to the disease. The aims of the present study were to explore comprehensive gene expressions/transcriptomes in periodontitis-affected gingival tissues, and to identify ...
ORGANISM(S): Homo sapiens 
2010-08-13 | E-GEOD-23586 | biostudies-arrayexpress
Sort   by:  
 Page size