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MetabolomicsPlasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.

OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and an established natural animal model for human epilepsy types with genetic and unknown etiology. However, the metabolic pathways underlying IE remain largely unknown. METHODS: Plasma samples of healthy...

2025-07-02 | MTBLS10915 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7711 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7713 | MetaboLights
TranscriptomicsTranscription profiling of human monocytes (U937 cell line) to assess the impact of curcumin on monocytes exposed to oxidative stress
Oxidative stress as a result of cigarette smoking is an important etiological factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways. The activity of the transcriptional co-repressor Histone deacetylase-2 (HDAC2) ...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-10896 | biostudies-arrayexpress
ProteomicsLabel-free quantitative crotonylproteomics of mouse ovaries-Chronic resistant stress (CRS) and control group, two repeats each
We found that in Chronic Resistant Stress (CRS)-treated mice, the fertility and oocyte quality significantly decreased, and plenty of biochemical indexes significantly changed, so we guessed that the overall physical health of CRS mice was severely impacted. As one major strategy to investigate the ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD028961 | Pride
Label-free quantitative crotonylproteomics Mouse ovaries Chronic resistant stress 
ProteomicsTMT-labeled quantitative phosphoproteomics of mouse ovaries-Chronic resistant stress (CRS), High salt (HS), Arecoline and control group, two repeats each
This batch of data is for three independent projects. Since in this three projects, the mouse strains are all CD1/ICR, the sex are both female, and the mouse ages are all two-month-old, three projects shared control data to save expenditure legitimately. But in our hand we couldn't segregate the raw...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD028932 | Pride
Quantitative phosphoproteomics Mouse ovaries Arecoline Chronic resistant stress High salt 
TranscriptomicsTranscription profiling of human chromic myeloid leukemia (CML) patients treated second-line with imatinib after failure of an interferon-alpha based therapy to identify genes with predictive value for primary cytogenetic outcome to imatinib
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-433 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD43+ cells from chronic-phase untreated CML patients vs controls to determine a molecular signature
Comparison of gene expression profiles of CD34+ hematopoietic stem and progenitor cells from bone marrow of patients with untreated chronic myelogenous leukemia (CML) in chronic phase with those from bone marrow of healthy volunteers. Chronic myelogenous leukaemia (CML) is a malignant disorder of th...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5550 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Roots and leaves Under High Osmotic Stress in Arabidopsis
The functions of miRNAs and their target mRNAs in Arabidopsis development have been widely documented, however, roles of stress responsive miRNAs and their targets are not as well understood. Using small RNA deep sequencing and ATH1 microarrays to profile mRNAs, we identified IAR3 (IAA-Ala Resistant...
ORGANISM(S): Arabidopsis thaliana 
2012-09-19 | E-GEOD-36789 | biostudies-arrayexpress
TranscriptomicsImportance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication.
Alcoholism is a relapsing disorder associated with excessive consumption after periods of abstinence. Neuroadaptations in brain structure, plasticity and gene expression occur with chronic intoxication but are poorly characterized. Here we report identification of pathways altered during abstinence ...
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-23165 | biostudies-arrayexpress
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