Sort   by:  
 Page size 
TranscriptomicsExpression data from ileum of mice suffered from subchronic and mild social defeat stress
This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-64004 | biostudies-arrayexpress
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress
TranscriptomicsBrain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of spleen, blood and hemi-brain of social stressed C57B6 mice exhibiting PTSD like features
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor's barrier avoidance, startled jumping, and retarded locomotion. Transcripts in s...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-68076 | biostudies-arrayexpress
ProteomicsiTRAQ-based proteomics suggests Ephb6 as a potential regulator of the ERK pathway in the prefrontal cortex of chronic social defeat stress model miceiTRAQ-based proteomics reveals Ephb6 as a potential regulator of the ERK pathway in the prefrontal cortex of chronic social defeat stress model mice
Purpose: Major depressive disorder (MDD) is a worldwide concern and devastating psychiatric disease. The World Health Organization claims that MDD leads to at least 11.9% of the global burden of disease. However, the underlying pathophysiology mechanisms of MDD remain largely unknown. Experimental ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD007573 | Pride
Major depressive disorder Prefrontal cortex Chronic social defeat stress Ephb6 Itraq 
GenomicsACF chromatin remodeling complex mediates stress-induced depressive-like behavior through nucleosome repositioning and transcriptional regulation.
Despite depression being one of the most prevalent and debilitating disorders worldwide, it has been difficult to understand its pathophysiology and to develop more effective treatments. Maladaptive transcriptional regulation within limbic neural circuits, including reward processing regions such as...
ORGANISM(S): Mus musculus 
2015-09-21 | E-GEOD-54263 | biostudies-arrayexpress
ProteomicsProteomics on dmPFC of chronic social defeat stress (CSDS) mice
We utilized the chronic social-defeat stress model (CSDS) to induce depressive-like phenotypes in mice . An unbiased quantitative proteomic screening was conducted on the dmPFC, a critical brain region for depression pathogenesis.
ORGANISM(S): Mus Musculus 
2022-12-06 | PXD037878 |
ProteomicsIdentifying Nucleus Accumbens Dysfunction in a novel mouse model of Female Social Defeat Stress (femCSDS) through proteomic profile
High-resolution label-free quantitative proteomics was performed on microdissected nucleus accumbens (NAc) tissue from female Mus musculus (C57BL/6NCrl) aged 6-8 weeks, subjected to a female chronic social defeat stress (femCSDS) paradigm and matched controls.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-25 | PXD074507 | Pride
Nucleus accumbens Mice Stress 
GenomicsSmall RNA Sequencing of mouse prefrontal cortex after chronic social defeat stress (CSDS)
Small RNA Sequencing of mouse prefrontal cortex after chronic social defeat stress (CSDS)
PRJNA491729 | ENA
GenomicsChronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in males
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in males
PRJNA1285977 | ENA
Sort   by:  
 Page size