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TranscriptomicsGenomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease
Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased 4 controls( beagle ...
ORGANISM(S): Canis lupus familiaris 
2008-05-15 | E-GEOD-11460 | biostudies-arrayexpress
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
TranscriptomicsInhibitory Role of Notch1 in Calcific Aortic Valve Disease
Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling ...
ORGANISM(S): Rattus norvegicus 
2011-08-25 | E-GEOD-31668 | biostudies-arrayexpress
TranscriptomicsGene expression from healthy male and female porcine aortic valve leaflets
Calcific aortic valvular disease (CAVD) is characterized by sclerosis of the aortic valve leaflets and recent clinical studies have linked several other risk factors to this disease, including male sex. In this study we examined potential sex-related differences in gene expression profiles between ...
ORGANISM(S): Sus scrofa 
2013-01-02 | E-GEOD-33654 | biostudies-arrayexpress
TranscriptomicsAortic valve transcriptome in CHIP, non-CHIP and non-calcific controls.
The aim of the present study was to gain insights on the pathological process of Calcific Aortic Valve Disease in CHIP carriers. To uncover molecular pathways that could link CHIP to CAVD, we exanimated the aortic valve transcriptome from CHIP, non-CHIP patients, or non-calcific controls with RNAseq...
ORGANISM(S): Homo sapiens 
2022-08-02 | E-MTAB-11354 | biostudies-arrayexpress
ProteomicsSerum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially d...
ORGANISM(S): Bos taurus (Bovine) 
2023-05-10 | PXD038475 | Pride
Myxomatous mitral valve disease Degenerative mitral valve disease Tmt proteomics Dogs Serum 
TranscriptomicsTranscription profiling of pig aortic valve exposure to two levels of cyclic mechanical pressure reveals mechanosensitive signalling pathways
Multiple molecular and cellular mechanisms are associated with the initiation and progression of aortic valve disease. Alterations in ECM remodeling, increased expression of pro-inflammatory cytokines, calcification, lipid deposition and changes in valve cell phenotype have demonstrated roles in dev...
ORGANISM(S): Sus scrofa 
2009-03-25 | E-GEOD-15211 | biostudies-arrayexpress
TranscriptomicsCharacterization of Heart Valve Leaflets from Adult and Juvenile Rapacz Familial Hypercholesterolemic Swine
Rapacz Familial Hypercholesterolemic (RFH) swine have been used extensively in the vascular biology field as a robust model of complex atherosclerotic lesions. However, the heart valves from RFH swine have not been evaluated and it is unknown whether these animals develop calcific aortic valve disea...
ORGANISM(S): Sus scrofa 
2014-01-11 | E-GEOD-53997 | biostudies-arrayexpress
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