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TranscriptomicsChronic Psychological Stress regulates Visceral Adipocyte-mediated Glucose Metabolism and Inflammatory Circuits in male Rats
In this study we employed the chronic unpredictable stress (CUS) rat model that leads to anxiety features comparable to humans and validated in several published reports as a well-characterized model of depression symptoms with high predictive validity. Cytokines and activated intracellular kinase l...
ORGANISM(S): Rattus norvegicus 
2014-06-03 | E-GEOD-47754 | biostudies-arrayexpress
ProteomicsChronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL/6 mice.
Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecu...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-31 | PXD035798 | Pride
Chronic variable stress Mouse Gastrocnemius muscle Isolated mitochondria Mitochondrial function 
TranscriptomicsSex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in fe...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-85136 | biostudies-arrayexpress
ProteomicsChronic stress targets mitochondrial respiratory efficiency in the skeletal muscle of C57BL/6 mice. PMID: 36988756
Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecu...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-08 | PXD042472 | Pride
Chronic variable stress Mouse Liver Isolated mitochondria Mitochondrial function 
no omics definedTranscription profiling of human mesenchymal stem cells exposed to different profiles of fluid flow-induced shear stress to investigate the effects on the MARK signaling pathway
Effect of different profiles of fluid flow-induced shear stress application on MAPK pathway gene expression in human mesenchymal stem cells
ORGANISM(S): Homo sapiens 
2009-11-24 | E-MEXP-1923 | biostudies-arrayexpress
GenomicsLong-term metabolic effect of chronic variable stress on liver function and the role of FGF21
Long-term metabolic effect of chronic variable stress on liver function and the role of FGF21
PRJNA666130 | ENA
GenomicsSex-biased single-cell genetic landscape in mice hippocampus with sub-chronic variable stress
Sex-biased single-cell genetic landscape in mice hippocampus with sub-chronic variable stress
PRJNA1295480 | ENA
ProteomicsChronic stress causes striatal disinhibition mediated by SOM-interneurons
Chronic stress is a major triggering factor for neuropsychiatric disorders including obsessive-compulsive disorder (OCD), a mental health condition characterized by motor stereotypies and striatal overactivation. However, the mechanisms at the cell- and microcircuit-level through which stress trigge...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-13 | PXD031193 | Pride
Striatum Swath-ms Chronic stress 
GenomicsExpression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]
Expression (Gene) in the endothelial cells of the mouse female prefrontal cortex (PFC) following 10-day chronic social stress or 6-day subchronic variable stress exposure [Female_CSDS_vs_SCVS]
PRJNA727167 | ENA
ProteomicsLong-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
Chronic stress leads post-traumatic stress disorder (PTSD) and to metabolic complications, including fatty liver. It is feasible, that stress immediately initiates molecular mechanisms to alter energy metabolism and glucose homeostasis which interfere with hepatic lipid accumulation after stress rec...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-10 | PXD025268 | Pride
Secreted proteins Fatty liver Mouse hepatocytes Long-term effects of chronic stress 
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