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TranscriptomicsA functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system
Copper is an essential component of cytochrome C oxidase (i.e. complex IV of the electron transport chain), and is thus critical for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-23 | E-GEOD-47175 | biostudies-arrayexpress
ProteomicsSolute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis
Ulcerative colitis (UC) patients have a greater risk of developing colorectal cancer through inflammation-dysplasia-carcinoma sequence of transformation. The histopathological diagnosis of dysplasia is therefore of critical clinical relevance, but dysplasia may be difficult to distinguish from infla...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD018679 | Pride
Dysplasia associated to inflammation Colorectal neoplasia Label-free proteomics 
ProteomicsLeishmania braziliensis Protein Arginine Methyltransferases interactomes
We functionally characterized the five predicted PRMTs in Leishmania braziliensis by gene knockout and endogenous protein HA tagging using CRISPR/Cas9 gene editing. We report that R-methylation profiles vary among Leishmania species and across L. braziliensis lifecycle stages, with the peak PRMT exp...
ORGANISM(S): Leishmania braziliensis 
2022-03-03 | PXD031057 | Pride
Leishmania braziliensis Prmt Protein arginine methyltransferase Gene knockout Crispr/cas9 
ProteomicsLeishmania Ribosomal Protein (RP) paralogous genes compensate each other’s expression maintaining protein native levels
We investigated the potential compensatory mechanism and possibility of noncanonical function of ribosomal proteins encoded by duplicated genes in Leishmania major.
ORGANISM(S): Leishmania major 
2024-06-03 | PXD047334 | Pride
Ribosomal proteins Compensatory mechanism. Duplicated genes Gene expression 
GenomicsA Genome-Wide Association Study of Lung Cancer Risk

Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types genotyping 515,922 single n...

phs000336.v1.p1 | EGA
UnknownQuality of life in MAP.3 (Mammary Prevention 3): a randomized, placebo-controlled trial evaluating exemestane for prevention of breast cancer.
Not available
S-EPMC4879707 | biostudies-literature
UnknownKisspeptin signaling in astrocytes modulates the reproductive axis.
Not available
S-EPMC11291270 | biostudies-literature
TranscriptomicsStrain abundance assay of barcoded DAmP loss of function S. cerevisiae strains exposed to various compounds
The ability to perform complex bioassays in parallel enables experiments otherwise impossible due to throughput and cost constraints. By way of example, highly parallel chemical-genetic screens using pooled collections of thousands of defined Saccharomyces cerevisiae gene deletion strains are feasib...
ORGANISM(S): Saccharomyces cerevisiae 
2008-07-03 | E-MEXP-1671 | biostudies-arrayexpress
UnknownBlood culture practices and microbiological capacity for sepsis diagnostics in Europe (2021-2022): a cross-sectional analysis of the European Sepsis Care Survey.
Not available
S-EPMC12771334 | biostudies-literature
UnknownNew-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry.
Not available
S-EPMC10834159 | biostudies-literature
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