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ProteomicsSerpinB2/TPPII regulates senescence
Tripeptidyl peptidase II (TPPII) degrades N-terminal tripeptides from proteins and peptides. Studies in both human and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation, and the aging process. However, the mechanism of how TPPII participates in these ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033808 | Pride
Activity-based probe  serine hydrolase  tpp  senescence  benzylphosphonofluoridate 
UnknownEngineered endolysin of Klebsiella pneumoniae phage is a potent and broad-spectrum bactericidal agent against "ESKAPEE" pathogens.
Not available
S-EPMC11112412 | biostudies-literature
UnknownSynthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection.
Not available
S-EPMC7112462 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
The CLS1/CAF co-culture maintained the cancer stemness. This cancer stemness was lost when the CAF feeder cells were removed during passaging. To investigate the specific signaling pathways and markers of lung CSCs, we analyzed the gene expression profile of the CLS1 sphere after CLS1/CAF co-cultur...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-38678 | biostudies-arrayexpress
Proteomics,MultiomicsAPOBEC3A is an Oral Cancer Prognostic Biomarker in Taiwanese Carriers of an APOBEC Deletion Polymorphism
Chen T-W, Lee C-C, Liu H, Wu C-S, Pickering CR, Huang P-J, et al., Nature Communications 8, Article number: 465 (2017) doi:10.1038/s41467-017-00493-9

Oral squamous cell carcinoma is a prominent cancer worldwide, p...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084250 | MassIVE
ProteomicsMining Missing Protein Landscape in Subcellular Proteome of Human Embryonic Stem Cells
Human embryonic stem cells (hESCs) have capacity of self-renewal and multi-lineage differentiation into derivatives of three germ layers that are of clinical importance for regeneration medicine. Despite the significant progress of hESCs study for clinical application, factors responsible for mainta...
ORGANISM(S): Homo Sapiens (human) 
2019-05-20 | PXD009840 | JPOST Repository
TranscriptomicsMeDIP-chip from clinical cervical tissues in promoters
Utilizing methylation DNA immunoprecipitation (MeDIP) coupled with promoter tiling arrays, we analyzed the methylation profiles of pooled DNA from human cervical carcinoma and normal cervix Cervical carcinoma compaire with normal cervix
ORGANISM(S): Homo sapiens 
2012-08-05 | E-GEOD-33187 | biostudies-arrayexpress
UnknownOxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a.
Not available
S-EPMC4351177 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
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