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ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
UnknownAssociation of Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Gene Polymorphisms with Autoimmune Thyroid Disease in Children and Adults: Case-Control Study.
Not available
S-EPMC4844099 | biostudies-literature
UnknownSingle-cell RNA-sequencing of BCG naive and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathway.
Not available
S-EPMC12475466 | biostudies-literature
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
TranscriptomicsBulk RNA-seq of immortalized N/TERT keratinocytes stimulated with IFNγ
Inflammasomes are multicomplex proteins which drive pro-inflammatory cytokine responses and pyroptosis in innate immunity. Of which, the NLRP3 inflammasome is the most extensively studied, especially in myeloid immune cells such as macrophages. Conversely, the regulation of NLRP3 in non-immune cell ...
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15754 | biostudies-arrayexpress
Proteomics,MultiomicsAPOBEC3A is an Oral Cancer Prognostic Biomarker in Taiwanese Carriers of an APOBEC Deletion Polymorphism
Chen T-W, Lee C-C, Liu H, Wu C-S, Pickering CR, Huang P-J, et al., Nature Communications 8, Article number: 465 (2017) doi:10.1038/s41467-017-00493-9

Oral squamous cell carcinoma is a prominent cancer worldwide, p...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084250 | MassIVE
UnknownMain-chain engineering of polymer photocatalysts with hydrophilic non-conjugated segments for visible-light-driven hydrogen evolution.
Not available
S-EPMC9482619 | biostudies-literature
ProteomicsPotential role of lysine acetylation in brown film formation and post-ripening of Lentinula edodes mycelium
Lentinula edodes is one of the most widely cultivated edible mushrooms in the world. When cultivated in sawdust, the surface mycelium of L. edodes needs a long post-ripening stage wherein it forms a brown film (BF) by secreting and accumulating pigments. BF formation is critical for the high quality...
ORGANISM(S): Lentinula Edodes 
2023-06-08 | PXD042811 |
UnknownAccuracy of the Canadian COVID-19 Mortality Score (CCMS) to predict in-hospital mortality among vaccinated and unvaccinated patients infected with Omicron: a cohort study.
Not available
S-EPMC11580276 | biostudies-literature
UnknownDevelopment of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study.
Not available
S-EPMC8096396 | biostudies-literature
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