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TranscriptomicsLoss of Olfactomedin 4 Leads to Neoplastic Progression in the Prostate
Purpose: To explore the mechanisms underlying increased tumorigenesis of Olfm4-deficient murine prostate. Experiment design: Comparison of gene expression between Olfm4-knockout and wild-type mice at 3 months of age in the prostate tissue. Experimental procedures: Total RNA was purified from whole p...
ORGANISM(S): Mus musculus 
2016-07-06 | E-GEOD-39989 | biostudies-arrayexpress
TranscriptomicsNegative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress
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