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UnknownVNTR2/VNTR3 genotype in the FCGRT gene is associated with reduced effectiveness of intravenous immunoglobulin in patients with myasthenia gravis.
Not available
S-EPMC7844454 | biostudies-literature
ProteomicsReactive Metabolite-induced Protein Glutathionylation Mechanistically Accounts for Acetaminophen Hepatotoxicity
Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...
ORGANISM(S): Homo Sapiens (human) 
2018-09-20 | PXD009986 | JPOST Repository
MetabolomicsGlobal Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress
“Dry eye” is a multi-factorial inflammatory disease affecting the ocular surface. Tear hyperosmolarity in dry eye contributes to inflammation and cell damage. Recent research efforts on dry eye have been directed towards biomarker discovery for diagnosis, response to treatment and disease mechanisms...
2015-08-31 | MTBLS214 | MetaboLights
UnknownRisk of Dementia or Cognitive Impairment in Sepsis Survivals: A Systematic Review and Meta-Analysis.
Not available
S-EPMC8959917 | biostudies-literature
UnknownS-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.
Not available
S-EPMC10847265 | biostudies-literature
UnknownCatalytic N-methyl amidation of carboxylic acids under cooperative conditions.
Not available
S-EPMC9284536 | biostudies-literature
MetabolomicsMultiple biochemical indices and metabolomics of Clonorchis sinensis provide a novel interpretation of biomarkers

BACKGROUND: Clonorchiasis, an infectious disease caused by the liver fluke Clonorchis sinensis, may lead to the development of liver and gallbladder diseases, and even cholangiocarcinoma (CCA). However, the pathogenesis, host-pathogen interaction, and diagnostic markers ...

2022-06-24 | MTBLS3306 | MetaboLights
MetabolomicsArginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy. Understanding how arginine depletion kills arginine-auxotrophic cancer cells will facilitate the development of anti-cancer therapeu...
2019-11-07 | MTBLS745 | MetaboLights
UnknownOptimizing Preventive Adjuvant Linac-Based (OPAL) Radiation: A Phase 2 Trial of Daily Partial Breast Irradiation.
Not available
S-EPMC11744773 | biostudies-literature
GenomicsIdentification of Recurrent NAB2-STAT6 Gene Fusions in Solitary Fibrous Tumor by Integrative Sequencing

Transcriptome sequencing of solitary fibrous tumors / hemangiopericytomas from a variety of anatomic sites revealed recurrent gene fusions between two genes, NAB2 and STAT6. All SFTs examined exhibited an in-frame fusion transcript encoding a fusion protein containing the EGR1 interaction domain ...

phs000567.v1.p1 | EGA
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