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ProteomicsThe Okur-Chung Neurodevelopmental Syndrome (OCNDS) mutation CK2K198R leads to a rewiring of kinase specificity
Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of casein kinase II (CK2). The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate the impact of this mutation, we first generated ...
ORGANISM(S): Escherichia coli 
2022-05-31 | PXD030823 | Pride
Ck2 Phosphorylation Okur-chung Ckii Kinase Phosphoproteomics Mutation Propel 
ProteomicsMetabolic remodelling in hiPSC-derived myofibres carrying the m.3243A>G mutation
Mutations in mitochondrial DNA cause severe multisystem disease, frequently associated with muscle weakness. The m.3243A>G mutation is the major cause of Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke Like episodes (MELAS). Experimental models that recapitulate the disease phenotype in v...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058785 | Pride
Mitochondria  mtdna  mtdna mutations  ipsc-derived myofibres 
MetabolomicsCharacteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a remarkable predominance in female, suggesting that steroid hormones may be involved in the pathogenesis. Herein, more than 70 kinds of steroids in urine were detected by gas chromatography/mass spectrometry (GC/MS) to reve...

2023-07-28 | MTBLS7766 | MetaboLights
MetabolomicsEffects of coronatine elicitation on growth and metabolic profiles of Lemna paucicostata culture
In this study, the effects of coronatine treatment on the growth, comprehensive metabolic profiles, and productivity of bioactive compounds, including phenolics and phytosterols, in whole plant cultures of Lemna paucicostata were investigated using gas chromatography-mass spectrometry (GC-MS) couple...
2018-09-11 | MTBLS526 | MetaboLights
UnknownTetra-kis(dimethyl-ammonium) trans-di-chloridobis[5,5'-(pyrazine-2,3-diyl)bis(1H-tetra-zol-1-ido-κN(1))]copper(II).
Not available
S-EPMC3470127 | biostudies-literature
TranscriptomicsChip-chip from Escherichia coli MG1655 K-12, WT and M-bM-^HM-^Ffnr strains
Mapping the occupancy of FNR, HNS, and IHF throughout the genome of Escherchia coli MG1655 K-12 using an affinity purified antibody under anerobic growth conditions. We also mapped the binding of the M-CM-^_ subunit of RNA Polymerase under both aerobic and anaerobic growth conditions. As a control, ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41186 | biostudies-arrayexpress
UnknownValidation of Biomarker-Based ABCD Score in Atrial Fibrillation Patients with a Non-Gender CHA2DS2-VASc Score 0-1: A Korean Multi-Center Cohort.
Not available
S-EPMC9520051 | biostudies-literature
UnknownDNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study.
Not available
S-EPMC4359265 | biostudies-literature
UnknownPaeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk.
Not available
S-EPMC7858273 | biostudies-literature
ProteomicsProfiling proteins regulated by putative methyltransferases in Xanthomonas axonopodis pv. glycines str. 8ra
- Identification of proteins whose expression was affected by three putative methyltransferases in Xanthomonas axonopodis pv. glycines str. 8ra - Shotgun proteomic analysis was used - Four strains were used with three biological replicates (total 12 samples). One is the wildtype carrying an empty ve...
ORGANISM(S): Xanthomonas axonopodis pv. glycines str. 8ra 
2019-11-11 | PXD012590 | Pride
Xanthomonas axonopodis pv. glycines Label-free shotgun proteomics Methyltransferase 
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