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UnknownEconomy-Sensitive Conditions: Are Some Pediatric Hospitalizations Triggered By Economic Recessions?
The impact of economic recessions on child health is complex and varied. Here we examine associations between county-level unemployment and pediatric hospitalizations in fourteen states every third year from 2002 to 2014. After adjusting for state-specific effects of unemployment across all counties...
S-EPMC8721748 | biostudies-literature
ProteomicsLarge-scale HDMSE mapping of the normal sputum proteome
Severe asthma is a collection of disease entities with varying pathophysiological characteristics that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD005949 | Pride
Label free Data independent Human Sputum 
UnknownThe genomics education partnership: successful integration of research into laboratory classes at a diverse group of undergraduate institutions.
Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Departmen...
S-EPMC2830162 | biostudies-literature
UnknownDrosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the ge...
S-EPMC4426361 | biostudies-literature
UnknownAssociation of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

Importance

Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists.

Objective

To identify mutation-specific cancer risks for carriers of BRCA1/2.

Design, setting, and participants

Observational study of women who ...
S-EPMC4537700 | biostudies-literature
UnknownGenetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.

Aim

To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.

Materials and methods

We included nearly 250,000 Finnish individuals who had visited a dentist in the public healthcare sector for a clinical ...
S-EPMC12377943 | biostudies-literature
UnknownIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC ...
S-EPMC5612337 | biostudies-literature
UnknownCortical Amyloid β Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment.
Depressive symptoms are frequently seen in patients with dementia and mild cognitive impairment (MCI). Evidence suggests that there may be a link between current depressive symptoms and Alzheimer disease (AD)-associated pathological changes, such as an increase in cortical amyloid-β (Aβ). However, l...
S-EPMC4870393 | biostudies-literature
UnknownFine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent ris...
S-EPMC6974400 | biostudies-literature
UnknownMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.

Importance

Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-making or trials, is unknown.

Objectives

To explore...
S-EPMC10762575 | biostudies-literature
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