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TranscriptomicsMethylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
Background: Methylphenidate (MPH) a psychostimulant prescribed to manage ADHD symptoms, has been increasingly prescribed to children not meeting the strict criteria for ADHD. It has also been misused as a “cognitive enhancer” and as an alternative to other psychostimulants. Here, we investigate whet...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-33619 | biostudies-arrayexpress
TranscriptomicsEfficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-68391 | biostudies-arrayexpress
ProteomicsComparative proteomic and metabolomic analysis of resistant and susceptible Kentucky Bluegrass cultivars in response to infection by powdery mildew
In this study, we first analyzed the disease incidence of different disease-resistant P. pratensis varieties, and then investigated changes in their in vivo redox states. Isobaric tags for relative and absolute (iTRAQ) proteomics and nontargeted metabolomics were utilized to elucidate the response m...
ORGANISM(S): Poa Pratensis 
2024-05-25 | PXD052577 |
TranscriptomicsA high-resolution map of active promoters in the human genome
Our ability to understand the control logic embedded in the human genome is limited by a lack of accurate information of the promoter sequences for most genes. Promoters are a unique class of control sequences, serving as the binding sites for both sequence-specific factors and the general transcri...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2672 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
ProteomicsResveratrol and N-acetylcystei reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma
we performed longitudinal, unbiased, quantitative proteomics using liver tissues from RES-treated and vehicle-treated DEN/HFD mice
ORGANISM(S): Mus Musculus 
2024-09-17 | PXD056132 |
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