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TranscriptomicsPreprocessed reduced representation bisulfite sequencing (RRBS) data from 173 human umbilical cord blood samples, collected for a study on associations between perinatal DNA methylation marks and progression to type 1 diabetes by age 15
The samples were collected from the participants of the Finnish Diabetes Prediction and Prevention (DIPP) Study, born between 1995 and 2006. DIPP is a prospective follow-up cohort of children with a moderate or high risk of type 1 diabetes, based on the HLA-DR-DQ genotype. Islet cell autoantibodies ...
ORGANISM(S): Homo sapiens 
2022-06-06 | E-MTAB-10530 | biostudies-arrayexpress
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownPuromycin-sensitive aminopeptidase: an antiviral prodrug activating enzyme.
Not available
S-EPMC2830364 | biostudies-literature
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
TranscriptomicsMhyo IG Rnd vs MhRnd
Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia and a major factor in the porcine respiratory disease complex. A clear understanding of the mechanisms of pathogenesis does not exist. The virulence factors of M. hyopneumoniae are largely unknown and are most probably com...
ORGANISM(S): Mycoplasma hyopneumoniae 
2010-06-30 | E-GEOD-17893 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of migratory vs sedentary brown trout (Salmo trutta) and wild vs hatchery Atlantic salmon (Salmo salar)
A total of 55 individuals were analysed: 15 migratory brown trout (Salmo trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Chevenne river, and 10 Atlantic salmon (S. salar) indivi...
ORGANISM(S): Salmo salar 
2006-03-27 | E-MEXP-123 | biostudies-arrayexpress
UnknownStochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA).
Not available
S-EPMC5920327 | biostudies-literature
TranscriptomicsTranscription profiling time series of cyanobacteria Prochlorococcus marinus subsp. pastoris str. CCMP1986 (MED4) and str. MIT 9313 grown in media with different levels and sources of nitrogen
Cyanobacteria Prochlorococcus marinus subsp. pastoris str. CCMP1986 (MED4) and Prochlorococcus marinus str. MIT 9313 (MIT9313) are oceanic oxygenic phototrophs, where MED4 is abundant in surface waters (~0-50 meters) and MIT9313 is abundant at depths of ~100 meters. To explore nitrogen-regulated cha...
ORGANISM(S): Prochlorococcus marinus 
2007-10-11 | E-TABM-91 | biostudies-arrayexpress
TranscriptomicsA binary redox control mode in gene expression and metabolism of plants
To analyze the impact of photosynthetic redox signals, light sources with spectral qualities that preferentially excite either Photosystem I (PSI light) or Photosystem II (PSII light) were used. The light sources have been described in (Fey et al., 2005). Strong reduction and oxidation signals were ...
ORGANISM(S): Arabidopsis thaliana 
2010-06-24 | E-GEOD-9235 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Ts65Dn vs control mice in nine different mouse tissues
To understand the molecular basis of Down syndrome pathogenesis, we performed a transcriptome analysis of nine different tissues in Ts65Dn, an established mouse model of human trisomy 21. Ts65Dn mice have segmental trisomy of mouse chromosome 16 with ca. 128 genes at dosage imbalance (Reeves et al. ...
ORGANISM(S): Mus musculus 
2004-04-23 | E-MEXP-102 | biostudies-arrayexpress
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