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GenomicsTherapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-55064 | biostudies-arrayexpress
TranscriptomicsTherapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (microarray)
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-55063 | biostudies-arrayexpress
GenomicsTherapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer (ChIP-Seq)
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling1-3. Despite the success of recently approved...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-55062 | biostudies-arrayexpress
GenomicsTargeting the MLL complex in castration-resistant prostate cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-60842 | biostudies-arrayexpress
GenomicsDevelopment of peptidomimetic inhibitors of the ERG transcription factor in prostate cancer (ChIP-seq)
Transcription factors play a key role in the development of a number of cancers, and therapeutically targeting them has remained a challenge. In prostate cancer, the ETS transcription factor ERG is recurrently rearranged and likely plays a critical role in prostate oncogenesis. Here we identified a ...
ORGANISM(S): Homo sapiens 
2014-07-15 | E-GEOD-58939 | biostudies-arrayexpress
GenomicsTargeting the MLL complex in castration-resistant prostate cancer [ChIP-seq]
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. The development and progression to CRPC following androgen ablation therapy is predominantly driven by unregulated androgen receptor (AR) signaling. Despite the success of recently approved ther...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-60841 | biostudies-arrayexpress
TranscriptomicsTargeting the MLL complex in castration-resistant prostate cancer [expression]
Resistance to androgen deprivation therapies and increased androgen receptor (AR) activity are major drivers of castration-resistant prostate cancer (CRPC). Prior work has focused on targeting AR directly; however, the identification and targeting of co-activators of AR signaling remains an underexp...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-60836 | biostudies-arrayexpress
TranscriptomicsBubble-seq Analysis of the Human Genome Reveals Distinct Chromatin-Mediated Mechanisms for Regulating Early- and Late-Firing Origins
We have devised a method for isolating virtually pure and comprehensive libraries of restriction fragments that contained replication initiation sites (bubbles) in vivo (Mesner et al. 2009). We have now sequenced and mapped the bubble-containing fragments from GM06990, a near-normal EBV-transformed...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-38809 | biostudies-arrayexpress
GenomicsHistone modification analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
We studied the extent of chromatin remodeling in an in-vitro model of the epithelial-mesenchymal transition (EMT). EMT is induced in spheroid cultures (3D) using simultaneously two cytokines: TGFbeta and TNFalpha. The epithelial-mesenchymal transition (EMT) is a cellular de-differentiation process t...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42374 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in TGFbeta/TNFalpha treated A549 spheroid cultures
TGFbeta/TNFalpha treated spheroid A549 cultures are a model of the epithelial-mesenchymal transition (EMT). These experiments capture the changes in global gene expression that result from cells being induced to undergo EMT (3D control vs 3D treated), but also the differences in gene expression when...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-42373 | biostudies-arrayexpress
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