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MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsBlood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation. From exposome to molecular responses
Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091157 | MassIVE
TranscriptomicsCigarette Smoking Induces Small Airway Epithelial Epigenetic Changes with Corresponding Modulation of Gene Expression
The small airway epithelium (SAE), the first site of smoking-induced lung pathology, exhibits genome-wide changes in gene expression in response to cigarette smoking. Based on the increasing evidence that the epigenome can respond to external stimuli in a rapid manner, we assessed the SAE of smokers...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-43079 | biostudies-arrayexpress
TranscriptomicsBiologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biol...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-11784 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Disarray of the Apical Junctional Complex Gene Expression Architecture in the Human Airway Epithelium
The apical junctional complex (AJC), composed of tight junctions and adherens junctions, is essential for maintaining epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are both associated with increased lung epit...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-20257 | biostudies-arrayexpress
MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
Genomics16S rRNA sequencing of fecal samples from Atg16l1 T300A and wildtype littermate mice that were exposed to mainstream cigarette smoking co-housed with mice from the same genotype but not exposed to cigarette smoking
We found that mainstream cigarette smoking (4 cigarettes/day, 5 days/week for 2 weeks using Kentucky Research Cigarettes 3R4F) resulted in >20% decrease in the percentage of normal Paneth cell population in Atg16l1 T300A mice but showed minimal effect in wildtype littermate control mice, indicating ...
ORGANISM(S): mouse gut metagenome 
2018-10-31 | E-MTAB-5720 | biostudies-arrayexpress
TranscriptomicsCigarette Smoking Induces Overexpression of a Fat Depleting Gene AZGP1 in the Human Airway Epithelium
Smokers weigh less and have less body fat than non-smokers, and increased body fat and weight gain are observed following smoking cessation. To assess a possible molecular mechanism underlying the inverse association between smoking and body weight, we hypothesized that smoking may induce the expres...
ORGANISM(S): Homo sapiens 
2009-01-06 | E-GEOD-10135 | biostudies-arrayexpress
TranscriptomicsSmoking Status Impacts microRNA Mediated Prognosis and Lung Adenocarcinoma Biology
Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on sm...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-62182 | biostudies-arrayexpress
Genomics16S rRNA sequencing of fecal samples from Atg16l1 T300A and wildtype littermate mice that were either exposed or not to mainstream cigarette smoking for 6 weeks
We found that mainstream cigarette smoking (4 cigarettes/day, 5 days/week for 2 weeks using Kentucky Research Cigarettes 3R4F) resulted in >20% decrease in the percentage of normal Paneth cell population in Atg16l1 T300A mice but showed minimal effect in wildtype littermate control mice, indicating ...
ORGANISM(S): mouse gut metagenome 
2018-10-31 | E-MTAB-5717 | biostudies-arrayexpress
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