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ProteomicsIn situ Proteomics of Brain Cilia Unveils Molecular Mechanisms of Cilia-Synapse Interactions
Neuronal cilia have emerged as pivotal signaling hubs; yet the ciliary molecules that organize signaling modalities and communication with neighboring synapses remain elusive. To map the brain cilia proteome, we engineered an Arl13b-TurboID mouse that enabled robust cilia-specific biotinylation in a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD067626 | Pride
Expansion microscopy Neuronal cilia Proximity proteomics Cilia-synapse interaction Synaptic signaling 
TranscriptomicsMethadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for OUD involve methadone, a synthetic opioid analgesic that attenuates withdrawal symptoms and behaviors linked with maternal drug abuse. However, methadone’s ability to readily...
ORGANISM(S): Homo sapiens 
2023-05-06 | GSE210682 | GEO
GenomicsMethadone alters transcriptional programs associated with synapse formation in human cortical organoids
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
PRJNA867025 | ENA
TranscriptomicsProfiling data on the developing olfactory/GnRH system reveal cellular and molecular pathways potentially relevant for the Kallmann syndrome.
The olfactory sensory system is formed by the coordinated morphogenesis and differentiation of the peripheral olfactory epithelium (OE) and the anterior forebrain. At early stages, immature olfactory receptor neurons (ORN) elongate their axons to penetrate the brain basement membrane, contact and fo...
ORGANISM(S): Mus musculus 
2014-01-31 | E-GEOD-52800 | biostudies-arrayexpress
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