Profiling data on the developing olfactory/GnRH system reveal cellular and molecular pathways potentially relevant for the Kallmann syndrome.

ABSTRACT: The olfactory sensory system is formed by the coordinated morphogenesis and differentiation of the peripheral olfactory epithelium (OE) and the anterior forebrain. At early stages, immature olfactory receptor neurons (ORN) elongate their axons to penetrate the brain basement membrane, contact and form synapses with projection neurons of the olfactory bulb primordium. Axonal elongation is accompanied by migration of the GnRH+ neurons, followed by their ingression in the septo-hypothalamic area of the forebrain. This process is specifically impaired in the KallmannM-bM-^@M-^Ys syndrome (KS), a disorder characterized by anosmia and central hypogonadism. A set of transcription factors are master regulators of olfactory connectivity and GnRH neuron migration. We explored the transcriptional ne

ORGANISM(S): Mus musculus

SUBMITTER: Paolo Provero 

PROVIDER: E-GEOD-52800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress