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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
TranscriptomicsRNA profiling of the dorsal root ganglia, spinal cord, and anterior cingulate cortex in mice with CFA-induced inflammatory pain
To investigate the molecular mechanisms underlying pain and emotion - related responses in the nervous system, this experiment focused on dorsal root ganglia (DRG), spinal cord (SC), and anterior cingulate cortex (ACC) tissues. Mice were divided into sham and complete Freund's adjuvant (CFA) - induc...
ORGANISM(S): Mus musculus 
2026-08-30 | E-MTAB-15797 | biostudies-arrayexpress
GenomicsBulk-tissue RNA-sequencing of anterior cingulate cortex samples derived from Lewy body disease patients
Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have...
EGAS00001005305 | EGA
ProteomicsProtein degradation targets in the anterior cingulate cortex during indirect fear conditioning
This project examined sex differences in the role of K48 polyubiquitination in the prefrontal cortex during the indirect acquisition (observing another animal undergo fear conditioning) of an auditory fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2024-12-02 | PXD046274 | Pride
Anterior cingulate cortex Sex differences Ubiquitin Ptsd K48 
TranscriptomicsAlzheimer's disease and the normal aged brain (steph-affy-human-433773)
Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnos...
ORGANISM(S): Homo sapiens 
2006-07-10 | E-GEOD-5281 | biostudies-arrayexpress
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
ProteomicsIdentification of Novel Biomolecular Characteristics and Bioinformatic Analyses of the Anterior Cingulate Cortex in Morphine-Dependent Mice via Proteomic Profiling
Impaired function of the anterior cingulate cortex (ACC) is widely recognized as a critical factor in drug dependence. This study aimed to investigate protein alterations in the ACC of morphine-dependent mice using 4D label-free quantitative proteomics. Procrustes analysis and Pearson correlation an...
ORGANISM(S): Mus Musculus 
2025-12-05 | PXD071619 |
GenomicsTranscriptome data of temporal and cingulate cortex in the Rett syndrome brain
Transcriptome data of temporal and cingulate cortex in the Rett syndrome brain
PRJNA527289 | ENA
TranscriptomicsGene expression profile of sporadic and PSEN1 early-onset Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Around 10% of cases present an age of onset before 65 years-old, which in turn can be divided in monogenic or familial AD (FAD) and sporadic early-onset AD (EOAD). Mutations in PSEN1, PSEN2 and APP genes have been linked with FA...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-39420 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse strains (10) across 7 brain regions
Survey of gene expression in ten common inbred strains of laboratory mouse. Seven brain regions examined: amygdala, basal ganglia, cerebellum, frontal cortex, hippocampus, cingulate cortex, olfactory bulb. Experiment Overall Design: Tissue from three animals was pooled on each array. Three biolog...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5055 | biostudies-arrayexpress
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