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ProteomicsDevelopmentally regulated sex differences in K48 polyubiquitination in the amygdala
This project examined if sex differences in K48 polyubiquitination in the amygdala were developmentally regulated. This used basolateral amygdala (BLA) samples collected from 4 and 9 week old male and female Sprague-Dawley rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-11-06 | PXD042021 | Pride
Sex differences Amygdala Ubiquitin Ptsd K48 
ProteomicsThe UBA-domain of Ubc1/Ube2K Facilitates the Assembly of K48-/K63-Branched Ubiquitin Chains
Assembly of polymeric ubiquitin (Ub) chains is an essential posttranslational protein modification that regulates widespread intracellular processes in eukaryotic cells. Factors and mechanisms that regulate the formation of Ub chains are key to the understanding of many cellular processes. The E2 en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD018651 | Pride
Ubc1/ube2k ubiquitin k48-/k63-branched ubiquitin prm 
ProteomicsTemporally graded K48 polyubiquitin targets in the male amygdala following contextual fear conditioning
Temporally graded K48 polyubiquitin targets in the male amygdala following contextual fear conditioning
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD070314 | Pride
Sex differences Amygdala Ubiquitin K48 
ProteomicsTemporally graded K48 polyubiquitin targets in the female amygdala following contextual fear conditioning
Temporally graded K48 polyubiquitin targets in the female amygdala following contextual fear conditioning
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD070255 | Pride
Sex differences Amygdala Ubiquitin K48 
ProteomicsK48 ubiquitin selectively targets oxidized proteins in vivo
Ubiquitin is a highly conserved eukaryotic protein responsible for regulating a variety of functions when conjugated to target proteins. Ubiquitin is essential, accumulates during the stress response, and is the canonical signal for protein degradation by the proteasome. Still, the function of ubiqu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-30 | PXD014173 | Pride
K48 ubiquitin Yeast Oxidation Oxidative stress 
ProteomicsSex differences in the role of K48 polyubiquitination in indirectly acquired fear memories
This project examined sex differences in the role of K48 polyubiquitination in the amygdala during the indirect acquisition (observing another animal undergo fear conditioning) of an auditory fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2024-12-02 | PXD041661 | Pride
Sex differences Consolidation Amygdala Memory Ubiquitin Ptsd K48 
ProteomicsUbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains encode signals defining the fates of their modified proteins. Ubiquitin chain-mediated proteasomal degradation is a widespread eukaryotic regulatory mechanism. Yet, heterogeneity of intracellular ubiquitination has precluded systematically comparing degradation capacities of differe...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD060731 | Pride
Ubiquitin K48 Deubiquitination K63 Protein degradation Proteasome Proteostasis Electroporation Ubiquitin code Branched ubiquitin chains 
UnknownAn Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Not available
S-EPMC7205571 | biostudies-literature
ProteomicsThe UBA domain of Ubc1 (Ube2K) Facilitates the Assembly of K48/K63-Branched Ubiquitin Chains
The assembly of a specific polymeric ubiquitin (Ub) chain on a target protein is a key event in the regulation of numerous cellular processes. Yet, the mechanisms that govern the selective synthesis of particular polyubiquitin signals remain enigmatic. The ubiquitin-conjugating (E2) enzymes Ubc1 in ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-02 | PXD022621 | Pride
Ubiquitin Ubc1 Ubc4 Yeast Branched 
ProteomicsThe deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1
The OTU deubiquitinase TRABID is highly tuned for the recognition and cleavage of K29 and K33-linked ubiquitin chains. Yet the cellular functions of these atypical ubiquitin signals remain unclear. Here, we compared the interactome of two different catalytically-dead TRABID constructs, one that lack...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD022703 | Pride
Ubiquitin K29/k48-linked polyubiquitin chain Ubiquitin thioesterase E3 ubiquitin ligase Deubiquitination Trabid Hectd1 Lc-ms/ms Polyubiquitin chain Protein degradation 
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