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ProteomicsIdentification of potential substrates of TRABID in HeLa cells using SILAC
Immune checkpoint blockades (ICBs) have been approved for treating multiple cancer types, but the response rate is limited for many solid tumors. Much efforts have been devoted to understand the mechanisms governing ICB therapy efficacy and the abundance of tumor-infiltrating lymphocytes is among th...
ORGANISM(S): Homo sapiens (Human) 
2023-05-11 | PXD035002 | Pride
Trabid 
GenomicsChronic airway inflammation in Drosophila lacking the A20-like protein Trabid
Chronic airway inflammation in Drosophila lacking the A20-like protein Trabid
PRJNA1193575 | ENA
UnknownThe deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
Not available
S-EPMC7948964 | biostudies-literature
ProteomicsThe deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1
The OTU deubiquitinase TRABID is highly tuned for the recognition and cleavage of K29 and K33-linked ubiquitin chains. Yet the cellular functions of these atypical ubiquitin signals remain unclear. Here, we compared the interactome of two different catalytically-dead TRABID constructs, one that lack...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD022703 | Pride
Ubiquitin K29/k48-linked polyubiquitin chain Ubiquitin thioesterase E3 ubiquitin ligase Deubiquitination Trabid Hectd1 Lc-ms/ms Polyubiquitin chain Protein degradation 
TranscriptomicsChronic airway inflammation in Drosophila lacking the A20-like protein Trabid
The long-term alteration of epithelial immune homeostasis is central to the development and persistence of chronic lung disease. Regulators of immune pathways, such as the NF-kB pathway, are critical in this context. A20 (tumor necrosis factor-α induced protein 3 (TNFAIP3)) is one of the inhibitors ...
ORGANISM(S): Drosophila melanogaster 
2025-09-24 | GSE283394 | GEO
UnknownTRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
Not available
S-EPMC10220035 | biostudies-literature
UnknownTrabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1.
Not available
S-EPMC6329825 | biostudies-literature
UnknownIdentification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.
Not available
S-EPMC3475094 | biostudies-literature
UnknownTrabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
Not available
S-EPMC10723793 | biostudies-literature
UnknownTRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.
Not available
S-EPMC10066190 | biostudies-literature
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