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ProteomicsThe E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Mechanistic studies of how protein ubiquitylation regulates the cell cycle, in particular during mitosis, have provided unique insights which have contributed to the emergence of the ‘Ubiquitin code’. In contrast to RING E3 ubiquitin ligases such as the APC/c ligase complex, the contribution of othe...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD035503 | Pride
Ubiquitin E3 ubiquitin ligase Cell proliferation Trabid Hectd1 Cell cycle 
ProteomicsThe deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1
The OTU deubiquitinase TRABID is highly tuned for the recognition and cleavage of K29 and K33-linked ubiquitin chains. Yet the cellular functions of these atypical ubiquitin signals remain unclear. Here, we compared the interactome of two different catalytically-dead TRABID constructs, one that lack...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD022703 | Pride
Ubiquitin K29/k48-linked polyubiquitin chain Ubiquitin thioesterase E3 ubiquitin ligase Deubiquitination Trabid Hectd1 Lc-ms/ms Polyubiquitin chain Protein degradation 
GenomicsLoss of Hectd1 disrupts muscle sarcomere assembly and causes combined desmin-nemaline myopathy
Loss of Hectd1 disrupts muscle sarcomere assembly and causes combined desmin-nemaline myopathy
PRJNA1138709 | ENA
TranscriptomicsLoss of Hectd1 disrupts muscle sarcomere assembly and causes combined desmin-nemaline myopathy
The sarcomere is the muscle contractile unit, whose assembly and disassembly are intimately linked to changes in myofiber size and function. Mutations in sarcomeric proteins are common causes of myopathies, ranging from severe neonatal to adult-onset forms. Here, we identify HECTD1 as an E3 ubiquiti...
ORGANISM(S): Mus musculus 
2024-07-26 | GSE272775 | GEO
UnknownCircHECTD1 mediates pulmonary fibroblast activation via HECTD1.
Not available
S-EPMC6887829 | biostudies-literature
UnknownHECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition.
Not available
S-EPMC7115742 | biostudies-literature
UnknownSequence variants in HECTD1 result in a variable neurodevelopmental disorder.
Not available
S-EPMC11947180 | biostudies-literature
UnknownCentriolin interacts with HectD1 in a cell cycle dependent manner.
Not available
S-EPMC10731774 | biostudies-literature
UnknowncircRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.
Not available
S-EPMC5743568 | biostudies-literature
UnknownThe deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.
Not available
S-EPMC7948964 | biostudies-literature
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