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Engram-specific transcriptome profiling of contextual memory consolidation
Neuron type-specific mRNA translation programs provide a gateway for memory consolidation.
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
Long-term memory consolidation is a dynamic process that requires a heterogeneous ensemble of neurons, each with a highly specialized molecular signature. Considerable effort has been devoted to identifying molecular changes that accompany the process of consolidation, but mostly hours or days after...
ORGANISM(S): Mus musculus 
2026-05-07 | GSE300675 | GEO
Genomics
Jiashan Land Consolidation
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation
Small noncoding RNAs (sncRNA) are becoming recognized for their participation in a diverse range of cellular functions. In this study, their global characterization in human spermatozoa from donors with proven fertility was undertaken. Reads were analyzed in two classes, those mapping to unique loca...
ORGANISM(S): Homo sapiens 
Swarming motility by the urinary tract pathogen Proteus mirabilis has been a long-studied, but little understood phenomenon. On agar, a P. mirabilis colony grows outward in a bullseye pattern formed by consecutive waves of rapid swarming followed by consolidation into shorter cells. To examine diffe...
ORGANISM(S): Proteus mirabilis HI4320 
2010-06-07 | GSE17897 | GEO
Sparse populations of neurons in the dentate gyrus (DG) of the hippocampus are causally implicated in the encoding of contextual fear memories. However, engram-specific molecular mechanisms underlying memory consolidation remain largely unknown. Here we perform unbiased RNA sequencing of DG engram n...
ORGANISM(S): Mus musculus 
2019-03-30 | GSE129024 | GEO
Consolidation of long-term memory (LTM) is a complex process requiring synthesis of new mRNAs and proteins. Many studies have characterized the requirement for de novo mRNA and protein synthesis; however, few studies have comprehensively identified genes regulated during LTM consolidation. We show t...
ORGANISM(S): Mus musculus 
2005-03-30 | GSE1782 | GEO
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