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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
TranscriptomicsRNA profiling of the dorsal root ganglia, spinal cord, and anterior cingulate cortex in mice with CFA-induced inflammatory pain
To investigate the molecular mechanisms underlying pain and emotion - related responses in the nervous system, this experiment focused on dorsal root ganglia (DRG), spinal cord (SC), and anterior cingulate cortex (ACC) tissues. Mice were divided into sham and complete Freund's adjuvant (CFA) - induc...
ORGANISM(S): Mus musculus 
2026-08-30 | E-MTAB-15797 | biostudies-arrayexpress
ProteomicsLocalised protein expression changes in different regions of human Alzheimer’s brain correlate with disease severity - Cingulate Gyrus
Human brain tissue was obtained from the New Zealand Brain Bank from donors with Alzheimer's disease (AD) or age-matched controls (n=9/group). Mean post mortem delays were ~12h. Six distinct brain regions were dissected, Hippocampus, Cingulate Gyrus, Entorhinal Cortex (severely affected), Motor and ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD008779 | Pride
Human Dementia Brain Alzheimer’s Cingulate gyrus Itraq 
TranscriptomicsAlzheimer's disease and the normal aged brain (steph-affy-human-433773)
Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnos...
ORGANISM(S): Homo sapiens 
2006-07-10 | E-GEOD-5281 | biostudies-arrayexpress
TranscriptomicsGene expression profile of sporadic and PSEN1 early-onset Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Around 10% of cases present an age of onset before 65 years-old, which in turn can be divided in monogenic or familial AD (FAD) and sporadic early-onset AD (EOAD). Mutations in PSEN1, PSEN2 and APP genes have been linked with FA...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-39420 | biostudies-arrayexpress
Otherintact Hi-C from posterior cingulate gyrus (ENCSR968JCS)
rush brain posterior cingulate gyrus healthy dnase hic For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf
ORGANISM(S): Homo sapiens 
2023-07-24 | GSE238042 | GEO
GenomicsBulk-tissue RNA-sequencing of anterior cingulate cortex samples derived from Lewy body disease patients
Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have...
EGAS00001005305 | EGA
TranscriptomicsGene expression profiling of high (HAB) vs. low (LAB) and normal (NAB) anxiety-related behavior mice in five laser microdissected brain regions.
Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-relat...
ORGANISM(S): Mus musculus 
2011-05-04 | E-GEOD-29014 | biostudies-arrayexpress
UnknownStructural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes.
Not available
S-EPMC10723245 | biostudies-literature
UnknownSurgical techniques and function outcome for cingulate gyrus glioma, how we do it.
Not available
S-EPMC9549335 | biostudies-literature
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