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ProteomicsComparative circadian proteomes in mouse liver under normal versus ECD conditions
Exam change in the whole-cell and nuclear proteome circadian proteome in response to environmental circadian disruption (ECD) in mouse liver
ORGANISM(S): Mus musculus (Mouse) 
2024-06-12 | PXD052085 | Pride
Circadian rhythms Liver Proteome 
ProteomicsCircadian Profiling of the Bone Marrow Derived Macrophage Proteome
Triplicate circadian time courses in synchronized macrophages sampling every 2 hours over 48 hours, starting at 16 hours post serum shock. Global proteome at each time point was quantified with 8 TMT10plex experiments.
ORGANISM(S): Mus musculus (Mouse) 
2021-02-12 | PXD022260 | Pride
Circadian Tandem mass tag Macrophage 
ProteomicsMouse Circadian Proteome Atlas by next-generation deep proteome analysis
The circadian clock drives daily rhythms of gene expression and physiological functions across tissues throughout the body. Advances in next-generation DNA sequencing have provided extensive insights into gene expression at the RNA level, but more functional information at the protein level with suf...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-27 | PXD069823 | Pride
Proteome analysis Phosphorylation Circadian clock 
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
ProteomicsInteractome of the circadian clock protein PERIOD2 in human U2OS osteosarcoma cells after the resetting of the circadian clock
Circadian rhythms are a series of endogenous autonomous 24-hour oscillations generated by the circadian clock. At the molecular level, the circadian clock is generated by a transcription-translation feedback loop, where BMAL1 and CLOCK transcription factors of the positive arm activate the expressio...
ORGANISM(S): Homo sapiens (Human) 
2022-04-22 | PXD025179 | Pride
Protein−protein interactions Proteomics Period2 Circadian clock Bioid 
ProteomicsMouse Circadian Proteome Atlas by next-generation deep proteome analysis
The circadian clock drives daily rhythms of gene expression and physiological functions across tissues throughout the body. Advances in next-generation DNA sequencing have provided extensive insights into gene expression at the RNA level, but more functional information at the protein level with suf...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-27 | PXD069794 | Pride
Orbitrap astral Circadian Phosphorylation 
ProteomicsA proteomics landscape of circadian clock in mouse liver
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
2018-06-25 | PXD008771 |
ProteomicsProteome analysis of Arabidopsis thaliana circadian clock mutants
The circadian clock is comprised of proteins that form negative feedback loops, which regulate the timing of global gene expression in a coordinated 24 hour cycle. As a result, the plant circadian clock is responsible for regulating numerous physiological processes central to growth and survival. To...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-01-02 | PXD004763 | Pride
Arabidopsis thaliana End of day End of night Circadian clock Shotgun Proteome 
ProteomicsSupplement data of project: A proteomics landscape of circadian clock in mouse liver
As a circadian organ, liver executes diverse functions in different phase of the circadian clock. This process is believed to be driven by a transcription program. Here, we present a TF DNA-binding activity centered multi-dimensional proteomics landscape, including DNA-binding activity of TFs, the p...
ORGANISM(S): Mus Musculus 
2018-06-25 | PXD008862 |
ProteomicsMouse Liver Circadian Proteome
The circadian clock is an evolutionary system that allows organisms to anticipate and thus adapt to daily changes in the environment. In mammals, the circadian clock is found in virtually every tissue regulating rhythms of metabolism and physiology. While a lot of studies have focused in how circadi...
ORGANISM(S): Mus musculus (Mouse) 
2014-04-14 | PXD000601 | Pride
Circadian proteome Mouse Liver 
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