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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
ProteomicsPeptidomics of circular cysteine-rich plant peptides – Analysis of the diversity of cyclotides from Viola tricolor by transcriptome- and proteome-mining
circular peptides, cystine-knot, transcriptome, peptidomics, Violaceae, ribosomally synthesized and post-translationally modified peptides natural products, mass spectrometry, 1kp
ORGANISM(S): Viola tricolor Viola tricolor subsp. tricolor 
2015-10-02 | PXD002867 | Pride
Peptidomics Ribosomally synthesized and post-translationally modified peptides natural products Transcriptome Mass spectrometry Cystine-knot 1kp Circular peptides Violaceae 
TranscriptomicsNatural circular RNA encodes regulatory small peptides in Mammalian cells
To test the hypothesis that circRNAs might encode functional peptides in mammalian cells, we studied the long intergenic non-protein coding RNA, p53 induced transcript (LINC-PINT), which was previously reported as a tumor suppressor and connected p53 activation with polycomb repressive complex 2 (PR...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74610 | biostudies-arrayexpress
TranscriptomicsNatural circular RNA encodes regulatory small peptides in Mammalian cells
To test the hypothesis that circRNAs might encode functional peptides in mammalian cells, we studied the long intergenic non-protein coding RNA, p53 induced transcript (LINC-PINT), which was previously reported as a tumor suppressor and connected p53 activation with polycomb repressive complex 2 (PR...
ORGANISM(S): Homo sapiens 
2015-11-04 | GSE74610 | GEO
ProteomicsChemical proteomics to elucidate target proteins of cysteine-stabilized and circular peptides
Cyclotides are circular and cystine-rich peptides which are little amenable to chemical modifications for probe design in chemical biology. The cyclotide [T20K]kalata B1 is an immune system modulating drug reported for its therapeutic application in multiple sclerosis.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2017-09-26 | PXD004798 | Pride
Peptide drug Target deconvolution Cyclotides Multiple sclerosis Target identification 
UnknownCircular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells.
Not available
S-EPMC3950807 | biostudies-literature
UnknownPan-cancer proteogenomic analysis reveals long and circular noncoding RNAs encoding peptides.
Not available
S-EPMC7418880 | biostudies-literature
UnknownDistinctive circular dichroism signature for 14-helix-bundle formation by beta-peptides.
Not available
S-EPMC2886586 | biostudies-literature
UnknownProtocol for reconstituting peptides/peptidomimetics from DMSO to aqueous buffers for circular dichroism analyses.
Not available
S-EPMC10839526 | biostudies-literature
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