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ProteomicsDisrupting CISD2 function in cancer cells primarily alters mitochondrial labile iron status and triggers reactive oxygen species accumulation
The multiple functions of CISD2 in cells could result from its role in calcium signaling, iron and/or iron-sulfur homeostasis, and/or ROS signaling/homeostasis. The relationship(s) and interdependency between these different signaling and homeostasis processes are however unclear at present, since m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087436 | MassIVE
GenomicsHMGCS2-PPARα signaling activates the prolongevity gene CISD2 to delay liver aging
HMGCS2-PPARα signaling activates the prolongevity gene CISD2 to delay liver aging
PRJNA1483465 | ENA
TranscriptomicsHMGCS2-PPARα signaling activates the prolongevity gene CISD2 to delay liver aging
Aging is a major risk factor for metabolic liver disorders, yet the molecular mechanisms driving hepatic aging remain incompletely understood. Here, we identify an HMGCS2-PPARα signaling pathway that regulates the prolongevity gene CISD2 and liver aging. Using naturally aged mice, we show that late-...
ORGANISM(S): Mus musculus 
2026-08-09 | GSE336868 | GEO
UnknownRejuvenation: Turning Back Time by Enhancing CISD2.
Not available
S-EPMC9695557 | biostudies-literature
UnknownIntracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum.
Not available
S-EPMC8482578 | biostudies-literature
UnknownCisd2 plays an essential role in corneal epithelial regeneration.
Not available
S-EPMC8577409 | biostudies-literature
UnknownUpregulation of Cisd2 attenuates Alzheimer's-related neuronal loss in mice.
Not available
S-EPMC7065100 | biostudies-literature
UnknownActivation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity.
Not available
S-EPMC12409322 | biostudies-literature
UnknownCisd2 is essential to delaying cardiac aging and to maintaining heart functions.
Not available
S-EPMC6799937 | biostudies-literature
UnknownRejuvenating the Aging Heart by Enhancing the Expression of the Cisd2 Prolongevity Gene.
Not available
S-EPMC8583758 | biostudies-literature
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