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Methylation profilingThe epigenetic and transcriptional basis of a developmental transition from brown to white adipose tissue
Brown and white adipose tissues are functionally and morphologically distinct. Theformer tissue has a primary role in maintaining thermogenesis in new born mammals while the latter acts as an energy storage vehicle that enhances survival when food is limiting. Both tissues are involved in maintainin...
ORGANISM(S): Ovis aries 
2018-07-01 | GSE70127 | GEO
GenomicsDNA Methylation in IMR90 cells
DNA methylation was measured by MBD2 enrichment of DNA fragments in IMR90. A statistical model was developed to estimate absolute methylation levels, and compared to whole genome bisulfite sequencing results (Lister, R. et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-38679 | biostudies-arrayexpress
UnknownKnown pathogenic gene variants and new candidates detected in sudden unexpected infant death using whole genome sequencing.
Not available
S-EPMC11706325 | biostudies-literature
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
UnknownPhase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine.
Not available
S-EPMC2799527 | biostudies-literature
UnknownPhase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine.
Not available
S-EPMC2810329 | biostudies-literature
GenomicsOvis aries
The epigenetic and transcriptional basis of a developmental transition from brown to white adipose tissue
PRJNA287692 | ENA
UnknownIn vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers.
Not available
S-EPMC3095594 | biostudies-literature
ProteomicsAmino acid priming of mTOR is essential for heart regeneration
For a short period of time in mammalian neonates, the mammalian heart can regenerate via cardiomyocyte proliferation. This regenerative capacity is largely absent in adults. In other organisms, including zebrafish, damaged hearts can regenerate throughout their lifespans. Many studies have been perf...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-15 | PXD011791 | Pride
Heart regeneration Mtor 
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
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