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TranscriptomicsExpression profiling in Wild-type and C-JUN knockout MEFs treated with IFNgamma and cycloheximide
STAT1 is the major transcription factor (TF) driving response to exposure to IFNg. C-JUN is a TF which has been shown to bind with STAT1 and act as a partner TF. We have expression profiled WT and CJUN-/- MEFs in order to determine the set of IFNg genes regulated by STAT1 and C-JUN. This study was d...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-26205 | biostudies-arrayexpress
UnknownMulti-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Not available
S-EPMC4872014 | biostudies-literature
GenomicsMutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors
Huntington's Disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N-terminus of the huntingtin (Htt) protein. Reactive microglia and elevated cytokine levels are observed in the brains of HD patients, but the extent to which neuroinflammation results f...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54443 | biostudies-arrayexpress
TranscriptomicsEmbryo methylation profiling in marmosets
Here we perform Bisulfite sequencing (BS-seq) on marmoset post-implantation embryos following laser capture micro dissection to capture methylation profiles of post-implantation tissues. We also perform single-cell BS-seq on pre-implantation marmoset embryos from four-cell to the compacted morula st...
ORGANISM(S): Callithrix jacchus 
2024-09-22 | E-MTAB-13893 | biostudies-arrayexpress
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsBulk ATAC-seq experiments on human samples from normal gastric cardia, normal oesophageal submucosal glands and Barrett's oesophagus tissue
Profiling open chromatin in different tissue types around the gastro-oesophageal junction to allow for clustering of samples and investigation of transcription factor binding site motif enrichment.
ORGANISM(S): Homo sapiens 
2021-08-24 | E-MTAB-10044 | biostudies-arrayexpress
UnknownAn allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response.
Not available
S-EPMC10411600 | biostudies-literature
ProteomicsComprehensive identification of full-length mRNA isoforms reveals massive diversity of neural cell-surface molecules and illuminates their function in development and disease
Genes encoding cell-surface proteins are crucial for nervous system development and are implicated in neurological disorders. These genes produce alternative mRNA isoforms which remain poorly characterized, impeding our understanding of how disease-associated mutations cause pathology. Here we intro...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD017290 | Pride
Cell-surface molecules Neural development Pacbio sequencing Isoforms 
ProteomicsETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription
The ETS transcription factor ELF5 drives mammary alveolar development in preparation for lactation by forcing differentiation within the progenitor cell population. In luminal A breast cancer, early disease progression is predicted by high levels of ELF5, and in preclinical models elevated ELF5 is a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013349 | Pride
Human Breast cancer Rime Estrogen activation 
TranscriptomicsHuman and marmoset trophoblast stem cells differ in signalling requirements and recapitulate divergent modes of trophoblast invasion
We derive experimental conditions for the derivation of marmoset trophoblast like cells. Marmoset naïve PSC form extraembryonic mesoderm in human TSC conditions, whilst TGFβ/NODAL, FGF/ERK and WNT signalling control marmoset peri- and postimplantation trophoblast identity.
ORGANISM(S): Callithrix jacchus 
2024-11-21 | E-MTAB-12463 | biostudies-arrayexpress
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