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TranscriptomicsThe role of Hoxa9 and Meis1 in development of acute myeloid leukemia (mRNA)
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX proteins, such as HOXA9, to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. To further resolve these mechanisms, we conducted a structure-function analysis of Meis1 and gene expression...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-75272 | biostudies-arrayexpress
ProteomicsTime-Resolved Analysis of Protein-Protein Ensembles using a Destabilizing Domain (TRAPPED) to resolve dynamic interactions of SARS-CoV-2 nsp15
Cellular protein-protein interactions are dynamic and can change over time. Current interactomics methods capture steady-state information but lack the ability to differentiate when the interactions occur. This study developed a post-translational method for synchronizing protein accumulation that a...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD063935 | Pride
Dihydrofolate reductase Proteomics Affinity purification-mass spectrometry Interactomics Destabilizing domain Virus-host protein interactions 
TranscriptomicsRNA-seq of pancreatic CAF-derived cell line 0082T treated with Autotaxin inhibitors (IOA-289 and PF-8380) against DMSO treated controls
Autotaxin (ATX), encoded by ENPP2, catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME). ATX is a clinical target in pancreatic ductal adenocarcinoma (PDAC), yet the pro-tumorigenic action of the ATX/LPA axis in PDAC remains unclear....
ORGANISM(S): Homo sapiens 
2024-10-06 | E-MTAB-14494 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of DNA from humans from different populations in self-self hybridizations, replicate experiments and independent validations of copy number variations to assess array performance
Data generated in the validation of a large-insert clone DNA microarray covering the entire human genome in tiling path resolution, which we have used to identify copy number variation in human populations. Array performance was extensively tested by a series of validation assays. These included...
ORGANISM(S): Homo sapiens 
2006-08-14 | E-TABM-123 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human blood samples spiked with one or two copies of individual human chromosomes to assess array performance
Data generated in the validation of a large-insert clone DNA microarray covering the entire human genome in tiling path resolution, which we have used to identify copy number variation in human populations. Array performance was extensively tested by a series of validation assays. These included...
ORGANISM(S): Homo sapiens 
2006-08-14 | E-TABM-124 | biostudies-arrayexpress
TranscriptomicsA gene expression fingerprint in mental retardation reflects disease causing defects in the histone demethylase KDM5
Mutations in KDM5C, (previously named SMCX or JARID1C) a gene that encodes a transcriptional regulator with histone-demethylase activity specific for di- and tri-methylated H3K4, are a comparatively frequent cause of non-syndromic X-linked mental retardation (NS-XLMR). Specific transcriptional targe...
ORGANISM(S): Homo sapiens 
2010-08-19 | E-GEOD-17369 | biostudies-arrayexpress
TranscriptomicsGene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non-Small Cell Lung Cancer (copy number data)
Hypothesis: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant event...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28572 | biostudies-arrayexpress
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